151132-95-5 Usage
Description
Nebularine CEP, also known as 2''-O-tert-Butyldimethylsilyl-5-O-DMT-nebularine 3''-CE phosphoramidite, is a chemical compound used in the preparation of cyclic dinucleotide compounds. These compounds act as modulators of the sting pathway, which plays a crucial role in the immune response.
Uses
Used in Pharmaceutical Industry:
Nebularine CEP is used as a key compound in the synthesis of cyclic dinucleotide compounds for modulating the sting pathway. This application is significant in the development of novel therapeutic strategies targeting the immune system, particularly in the context of autoimmune diseases and cancer.
Used in Research and Development:
In the field of research and development, Nebularine CEP serves as an essential tool for studying the mechanisms and functions of the sting pathway. This knowledge can lead to the discovery of new drug targets and the development of innovative treatments for various diseases.
Used in Drug Synthesis:
Nebularine CEP is utilized as a building block in the synthesis of cyclic dinucleotide compounds, which have potential applications in the pharmaceutical industry. These compounds can be used as modulators of the sting pathway, offering new avenues for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 151132-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,1,3 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 151132-95:
(8*1)+(7*5)+(6*1)+(5*1)+(4*3)+(3*2)+(2*9)+(1*5)=95
95 % 10 = 5
So 151132-95-5 is a valid CAS Registry Number.
151132-95-5Relevant articles and documents
Synthesis and stability of GNRA-loop analogs
Woerner, Karlheinz,Strube, Thorsten,Engels, Joachim W.
, p. 2094 - 2104 (1999)
Nebularinc, 9-(β-D-ribofuranosyl)-9H-purin-2-amine, and inosine phosphoramidites 8, 16, and 17, respectively, were synthesized and incorporated into the GNRA tetraloop at different positions (see Scheme, Table, and Fig. 4). The oligomers were investigated by means of UV and CD spectroscopy to address the question of how the individual base-modified N- nuclcosides contribute to changes in H-bonding and base-stacking interactions within the loop. Several CD spectra are given and compared with each other (Figs 5 and 6). The exchange of the loop sequence in position 4 and 7 results in a distinct change in base stacking. CD-Band shifting allows us to advance the hypothesis that a transition from a GNRA-type towards a UNCG-type base stacking is observed.
