1511857-25-2

Basic information

• Product Name: (E)-4-(3,5-dimethoxystyryl)phenyl 2-acetoxybenzoate
• Synonyms: (E)-4-(3,5-dimethoxystyryl)phenyl 2-acetoxybenzoate
• CAS NO: 1511857-25-2
• Molecular Weight: 418.446
• Mol File: 1511857-25-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-4-(3,5-dimethoxystyryl)phenyl 2-acetoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(3,5-dimethoxystyryl)phenyl 2-acetoxybenzoate(1511857-25-2)
• EPA Substance Registry System: (E)-4-(3,5-dimethoxystyryl)phenyl 2-acetoxybenzoate(1511857-25-2)

Safety Data

• Hazardous Substances Data: 1511857-25-2(Hazardous Substances Data)

Upstream product

• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 
• 5538-51-2 O-acetylsalicyloyl chloride 

Relevant articles and documents

Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

(Graph Presented). Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized a novel class of resveratrol-based aspirin prodrugs to simultaneously release aspirin and resveratrol to attenuate the side effects caused by aspirin. Prodrug RAH exerted enhanced anticancer activities which are better than a physical mixture of aspirin and resveratrol as well as each individually. Metabolism of RAH in mice showed that the majority of RAH is decomposed to release resveratrol and aspirin or salicylic acid either in the intestine or after absorption. Mechanistic studies demonstrate RAH inhibits cell cycle arrest through downregulation of cyclins and induces apoptosis by activation of caspase-3 in cancer cells. These findings highlighted the improved anticancer properties of resveratrol-based aspirin prodrugs. RAH may represent novel and safe alternatives of aspirin for the purpose of daily use in the future.