151271-08-8 Usage
Description
Imidazenil is an imidazobenzodiazepine with the profile of a partial agonist, characterized by its anxiolytic and anticonvulsant properties. It has been shown to attenuate benzodiazepine-induced cognition deficits in monkeys and does not produce sedation or ataxia in rats. Additionally, it does not potentiate the effects of alcohol. Imidazenil has a low intrinsic activity at the GABAA receptor, causing only a slight enhancement of GABA-ergic tone. However, its efficacy may increase when GABA tone is reduced, making it potentially active only in conditions where GABA tone is altered. This unique characteristic positions imidazenil as a promising treatment for anxiety and epilepsy.
Uses
Used in Pharmaceutical Industry:
Imidazenil is used as an anxiolytic and anticonvulsant drug for the treatment of anxiety and epilepsy. Its low intrinsic activity at the GABAA receptor and ability to be active only in conditions where GABA tone is altered make it an ideal candidate for these applications.
Used in Research and Development:
Imidazenil is used as a research tool to study the effects of benzodiazepines on cognition and to develop new treatments for anxiety and epilepsy. Its unique properties allow for a better understanding of the underlying mechanisms of these conditions and the potential development of more targeted and effective therapies.
Used in Clinical Trials:
Imidazenil is used in clinical trials to evaluate its safety, efficacy, and potential side effects as a treatment for anxiety and epilepsy. These trials help determine the optimal dosage and administration methods, as well as assess its overall effectiveness in treating these conditions.
Side effects
When taken by mouth: Ostarine is possibly unsafe. It might cause liver damage and other serious side effects such as heart attack.
Synthesis
The synthesis of?imidazenil is as follows:A mixture of 3 g (7.5 mmol) of 6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 300 mL of methylene chloride and 2.25 g (10.8 mmol) of phosphorus pentachloride was stirred at room temperature for 2 hours. Ammonia gas was then introduced until the mixture was basic. After layering with 20 mL of concentrated aqueous ammonia, the mixture was stirred for 15 minutes. The methylene chloride was washed with water, dried and evaporated. The residue was crystallized from ethanol/water to yield 2.4 g of product having the above formula. A second crop of 0.4 g was obtained from the mother liquor for a total yield of 2.8 g. For analysis, a sample of the product was recrystallized from methylene chloride/ethanol and had m.p. 298°-299° C.
Check Digit Verification of cas no
The CAS Registry Mumber 151271-08-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,2,7 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 151271-08:
(8*1)+(7*5)+(6*1)+(5*2)+(4*7)+(3*1)+(2*0)+(1*8)=98
98 % 10 = 8
So 151271-08-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H12BrFN4O/c19-13-4-2-1-3-11(13)16-12-7-10(20)5-6-14(12)24-9-23-17(18(21)25)15(24)8-22-16/h1-7,9H,8H2,(H2,21,25)
151271-08-8Relevant articles and documents
Synthesis of iodine-123 labelled analogues of imidazenil and ethyl-imidazenil for studying benzodiazepine receptors using SPECT
Katsifis, Andrew,Mattner, Filomena,Dikic, Branko,Najdovski, Ljubco,Kassiou, Michael
, p. 1121 - 1132 (2007/10/03)
The [123I]iodinated analogues of the benzodiazepine receptor partial agonist imidazenil and N-ethyl imidazenil have been synthesised for the study of the central benzodiazepine receptor using SPECT. [123I]Iodoimidazenil and [123
