1512812-53-1

Basic information

• Product Name: 3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine
• CAS NO: 1512812-53-1
• Molecular Weight: 264.25
• Mol File: 1512812-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine(1512812-53-1)
• EPA Substance Registry System: 3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine(1512812-53-1)

Safety Data

• Hazardous Substances Data: 1512812-53-1(Hazardous Substances Data)

Relevant articles and documents

Synthesis of Pyridobenzazepines Using a One-Pot Rh/Pd-Catalyzed Process

In recent years, our group has been developing multicatalytic reactions for the synthesis of biologically relevant heterocyclic compounds. An efficient dual-metal catalyzed reaction of electron-deficient o-chlorovinylpyridines with o-aminophenylboronic esters to access pyridobenzazepines is described. Combining a RhI-catalyzed arylation followed by a Pd0-catalyzed C-N coupling, in a one-pot procedure, provides a simplified method to access heterocycles without workup and purification after each step. The substrate scope encompasses a variety of N-H and N-alkylated pyridobenzazepine variants with yields up to 93%.