1513-65-1 Usage
Description
2,6-Difluoropyridine is a colorless to light yellow liquid that has been studied using various spectroscopic and computational methods. It is known for its ortholithiation reactions mediated by lithium diisopropylamide (LDA) in tetrahydrofuran at -78°C.
Uses
Used in Chemical Synthesis:
2,6-Difluoropyridine is used as a reactant in the preparation of poly(pyridine ether)s through polycondensation with silylated 1,1,1-tris(4-hydroxyphenyl)ethane. This application takes advantage of its reactivity and ability to form new compounds with potential applications in various industries.
Used in Research and Development:
In the field of research and development, 2,6-difluoropyridine serves as a valuable compound for studying ortholithiation reactions and understanding its chemical properties. This knowledge can be applied to develop new synthetic routes and improve existing ones, leading to the creation of novel materials and compounds with diverse applications.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2,6-difluoropyridine, due to its unique chemical structure and reactivity, could potentially be used in the pharmaceutical industry as a building block for the synthesis of various drug candidates. Its ability to form poly(pyridine ether)s may be particularly useful in the development of new medicinal compounds with specific biological activities.
Used in Material Science:
Similarly, the potential use of 2,6-difluoropyridine in material science is not explicitly stated in the materials provided. However, given its role in the synthesis of poly(pyridine ether)s, it is reasonable to infer that this compound could be utilized in the development of new materials with specific properties, such as improved thermal stability, chemical resistance, or electrical conductivity, depending on the final application.
Check Digit Verification of cas no
The CAS Registry Mumber 1513-65-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,1 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1513-65:
(6*1)+(5*5)+(4*1)+(3*3)+(2*6)+(1*5)=61
61 % 10 = 1
So 1513-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H4F3N3O/c6-5(7,8)2-1-3(12)11-4(9)10-2/h1H,(H3,9,10,11,12)
1513-65-1Relevant articles and documents
Highly reactive and regenerable fluorinating agent for oxidative fluorination of aromatics
Janmanchi, Krishna Murthy,Dolbier Jr., William R.
, p. 349 - 354 (2008)
A newly synthesized copper aluminum fluoride of nominal composition CuAl2F8 exhibits excellent reactivity towards direct oxidative fluorination of aromatic compounds, as well as fluorodechlorination of chloroaromatics. The spent CuAl2F8 reagent can be regenerated by treatment with O2 and HF, and the fluorination process has been demonstrated to retain high conversions through 20 reaction cycles. The main advantages of this new process are safety, minimal waste, and potentially low cost.
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Lui et al.
, p. 583 (1978)
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PROCESS FOR FLUORINATING COMPOUNDS
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Page/Page column 29; 33; 35, (2017/02/28)
Disclosed are mild temperature (e.g., from 0 to 80°C) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.
Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes
Ryan, Sarah J.,Schimler, Sydonie D.,Bland, Douglas C.,Sanford, Melanie S.
supporting information, p. 1866 - 1869 (2015/04/27)
The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.
