151303-19-4Relevant articles and documents
Synthesis of lipoxygenase inhibitors. Part 2: Synthesis of lactamarylhydrazones and tetrahydroazepinochinazolinon-arylhydrazones
Lettau,Buge,Harenberg,Hartel,Jarmer,Koch,Poppel,Schikora,Schneider,Weber,Nuhn
, p. 410 - 414 (2007/10/02)
The synthesis of lactamarylhydrazones as cyclic amidrazones is described starting from 5-, 6- and 7-membered lactames. Tetrahydroazepinochinazolinonarylhydrazones were prepared from caprolactam. The compounds were tested against soja lipoxygenase. A few compounds were very strong inhibitors (IC50 value up to 4.10-9 mol/l).
