1514-26-7

Basic information

• Product Name: M-(4-FLUOROPHENOXY)TOLUENE
• Synonyms: fluorophenoxytoluene;4-FLUOROPHENYL M-TOLYL ETHER;4-FLUORO-3'-METHYLDIPHENYL ETHER;M-(4-FLUOROPHENOXY)TOLUENE;4-Fluoro-3'-methyldiphenyl Ether 4-Fluorophenyl m-Tolyl Ether;m-(4-Fluorophenoxy)toluene;1-(4-Fluorophenoxy)-3-methylbenzene
• CAS NO: 1514-26-7
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.22
• Mol File: 1514-26-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.12
• Refractive Index: 1.5510 to 1.5550
• CAS DataBase Reference: M-(4-FLUOROPHENOXY)TOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: M-(4-FLUOROPHENOXY)TOLUENE(1514-26-7)
• EPA Substance Registry System: M-(4-FLUOROPHENOXY)TOLUENE(1514-26-7)

Safety Data

• Hazardous Substances Data: 1514-26-7(Hazardous Substances Data)

Usage

General Description

M-(4-Fluorophenoxy)toluene is a synthetic chemical compound that is mainly used in the field of organic synthesis. It is characterized by the presence of a fluorine atom and is often used in aromatic substitution reactions. M-(4-FLUOROPHENOXY)TOLUENE is soluble in most organic solvents and is often used as a reagent or precursor in the synthesis of more complex chemicals. Its molecular formula is C13H11FO and it is also identified by the CAS number 452-86-8. It should be handled with caution as it may cause skin and eye irritation and may be harmful if swallowed or inhaled. It's typically stored in a cool place in tightly closed containers.

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 371-41-5 4-Fluorophenol 
• 591-17-3 meta-bromotoluene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 371-41-5 4-Fluorophenol 

Relevant articles and documents

Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approach

Incorporation of fluorine in a drug can dramatically affect its metabolism and methods to assess the effect of fluorine substitution on drug metabolism are required for effective drug design. Employing a previously developed chemical-microbial method the metabolism of a series of fluorinated biphenyl ethers was determined. The substrates were synthesized via Ullmann-type condensation reactions between bromotoluene and fluorophenol. The ethers were incubated with the fungus Cunninghamella elegans, which oxidises xenobiotics in an analogous fashion to mammals, generating a number of hydroxylated biphenyl ethers and acids. The propensity of the fluorinated ring to be hydroxylated depended upon the position of the fluorine atom, and the oxidation of the methyl group was observed when it was meta to the oxygen. The experiments demonstrate the applicability of the method to rapidly determine the effect of fluorine substitution on CYP-catalysed biotransformation of pro-drug molecules.

N-[1-(3-phenoxyphenyl)ethyl]acetohydroxamic acid compounds which are useful anti-inflammatory agents

The present invention provides compounds of formula (II) STR1 wherein q is 1, and p is 1; Ar is phenyl optionally substituted by one or more substitutents independently selected from C1-4 alkyl (which may be substituted by one or more halogen a

Anti-inflammatory aryl derivatives

The present inventions concerned with compounds of formula (I) wherein, Ar is 4-halophenyl;, Ar? is 1,3- or 1,4-phenylene;, Y is (E)-CH=CH-; and, R1 and R2 are independently selected from hydrogen and C1-4alkyl;, and base salts and physiologica