15147-67-8 Usage
General Description
1-[5-O-(methylsulfonyl)pentofuranosyl]pyrimidine-2,4(1H,3H)-dione, also known as MSMPD, is a chemical compound that consists of a pyrimidine ring with a pentofuranosyl group attached at the 5-position and a methylsulfonyl group attached to the pentofuranosyl group. 1-[5-O-(methylsulfonyl)pentofuranosyl]pyrimidine-2,4(1H,3H)-dione is a derivative of the nucleoside thymidine and is synthesized by the reaction of thymidine with methylsulfonyl chloride. MSMPD is used in the pharmaceutical industry for the synthesis of nucleoside analogs, which have potential applications as antiviral and anticancer drugs. Studies have shown that MSMPD and its derivatives exhibit promising biological activities, making them valuable compounds for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 15147-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,4 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15147-67:
(7*1)+(6*5)+(5*1)+(4*4)+(3*7)+(2*6)+(1*7)=98
98 % 10 = 8
So 15147-67-8 is a valid CAS Registry Number.
15147-67-8Relevant articles and documents
Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition
Tiecco, Matteo,Di Profio, Pietro,Germani, Raimondo,Savelli, Gianfranco
experimental part, p. 911 - 923 (2010/09/04)
Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.
