151507-09-4

Basic information

• Product Name: 3-(Difluoromethyl)-5-(4-methoxyphenyl)-1-[4(methylthio)phenyl]pyrazole
• CAS NO: 151507-09-4
• Molecular Weight: 346.401
• Mol File: 151507-09-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(Difluoromethyl)-5-(4-methoxyphenyl)-1-[4(methylthio)phenyl]pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Difluoromethyl)-5-(4-methoxyphenyl)-1-[4(methylthio)phenyl]pyrazole(151507-09-4)
• EPA Substance Registry System: 3-(Difluoromethyl)-5-(4-methoxyphenyl)-1-[4(methylthio)phenyl]pyrazole(151507-09-4)

Safety Data

• Hazardous Substances Data: 151507-09-4(Hazardous Substances Data)

Upstream product

• 51304-69-9 4-(methylthio)phenylhydrazine 
• 189347-40-8 4,4-difluoro-1-(4-methoxy-phenyl)-butane-1,3-dione 

Relevant articles and documents

Studies on anti-inflammatory agents. V. Synthesis and pharmacological properties of 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4- (methylsulfinyl)phenyl]pyrazole and related compounds

A series of novel 1,5-diphenylpyrazole derivatives hearing hydrophilic substituents was prepared. The anti-inflammatory and analgesic activities of these compounds were evaluated by using the adjuvant arthritis and Randall- Selitto assays in rats, and the structure-activity relationships were studied. The optimal compound was 3-(difluoromethyl)-1 -(4-methoxyphenyl)-5- [4-(methylsulfinyl)phenyl]pyrazole (10) with oral Ed50 values of 0.31 and 2.6mg/kg on adjuvant-induced arthritis and carrageenin-induced foot edema, respectively. Compound 10 showed analgesic activities not only toward inflamed paw but also toward normal paw (ED30=0.55 and 1.8mg/kg, respectively) in the Randall-Selitto assay, and moreover, 10 was effective in the tail-pinch assay (ED50=21 mg/kg) similarly to morphine. The asymmetric synthesis and pharmacological properties of the enantiomers of 10 are also reported.