1516-38-7Relevant articles and documents
Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds
Benhida, Rachid,Demange, Luc,Dufies, Maeva,Grytsai, Oleksandr,Hagege, Anais,Martial, Sonia,Pagès, Gilles,Penco-Campillo, Manon,Ronco, Cyril,Valiashko, Oksana
, (2020/10/02)
Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.
Design and synthesis of new derivatives of 3H-quinazolin-4-one as potential anticonvulsant agents
Kabra, Uma,Chopde, Chandrabhan,Wadodkar, Sudhir
experimental part, p. 1351 - 1355 (2012/01/12)
As a part of systematic investigation on synthesis and biological activities, some new derivatives of 2-ethyl-3-(substituted benzothiazole- 2′-yl)-[3H]-quinazolin-4-ones 3 have been synthesized, and the structures of the compounds were confirmed by elemental analysis and spectral data. The newly synthesized derivatives are then screened for anticonvulsant activity by maximal electroshock method. Copyright
SYNTHESIS OF 2-AMINO-3-ETHOXYBENZENETHIOL AND ITS CONVERSION INTO 4H-1,4-BENZOTHIAZINES
Gupta, Radha Raman,Kumar, Rakesh
, p. 87 - 91 (2007/10/02)
Synthesis of 2-amino-3-ethoxybenzenethiol and 5-ethoxy-4H-1,4-benzothiazines is reported for the first time.Synthesis of 4H-1,4-benzothiazines involves the condensation and oxidative cyclization of 2-amino-3-ethoxybenzenethiol with β-diketones in DMSO.
