15175-18-5

Basic information

• Product Name: Cyclohexanone, 2-chloro-4-(1,1-dimethylethyl)-, trans-
• CAS NO: 15175-18-5
• Molecular Formula: C10H17ClO
• Molecular Weight: 188.697
• Mol File: 15175-18-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-chloro-4-(1,1-dimethylethyl)-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-chloro-4-(1,1-dimethylethyl)-, trans-(15175-18-5)
• EPA Substance Registry System: Cyclohexanone, 2-chloro-4-(1,1-dimethylethyl)-, trans-(15175-18-5)

Safety Data

• Hazardous Substances Data: 15175-18-5(Hazardous Substances Data)

Upstream product

• 98-53-3 4-tercbutyl-cyclohexanone 
• 21862-63-5 trans-4-tert-butylcyclohexanol 
• 19980-19-9 4-t-butyl-1-trimethylsilyloxy-1-cyclohexene 
• 66323-98-6 tert-butyl(4-tert-butylcyclohex-1-enyloxy)dimethylsilane 

Downstream Products

• 62845-84-5 4-(tert-butyl)cyclohex-1-en-1-yl diisopropyl phosphate 
• 62845-83-4 4-(tert-butyl)cyclohex-1-en-1-yl diethyl phosphate 
• 937-07-5 4-tert-butylcyclohex-2-enone 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 88589-67-7 (Z)-trans-4-tert-Butyl-2-chlorocyclohexan-1-one oxime 
• 88589-66-6 (E)-trans-4-tert-Butyl-2-chlorocyclohexan-1-one oxime 
• 17002-13-0 trans-t-butyl-4 cis-chloro-2 cyclohexanol 
• 16508-33-1 cis-4-tert-butyl-2-chlorocyclohexanone 
• 62845-82-3 Phosphoric acid 4-tert-butyl-cyclohex-1-enyl ester dimethyl ester 
• 42974-01-6 (2R*,4S*)-4-(t-butyl)-2-phenyl-1-cyclohexanone 

Relevant articles and documents

CONFORMATIONAL EQUILIBRIA IN HALOCYCLOHEXANONES, AN NMR AND SOLVATION STUDY

The conformational equilibrium in 2-chloro-cyclohexanone is measured in thirteen solvents from the 220 MHz 1H NMR spectrum, using the C2-H couplings and chemical shifts and the cis and trans-4-t-butyl-2-chlorocyclohexanones as refere

Direct conversion of alcohols to α-chloro aldehydes and α-chloro ketones

Direct conversion of primary and secondary alcohols into the corresponding α-chloro aldehydes and α-chloro ketones using trichloroisocyanuric acid, serving both as stoichiometric oxidant and α-halogenating reagent, is reported. For primary alcohols, TEMPO has to be added as an oxidation catalyst, and for the transformation of secondary alcohols (TEMPO-free protocol), MeOH as an additive is essential to promote chlorination of the intermediary ketones.

Catalytic cross-coupling of alkylzinc halides with α-chloroketones

The cross-coupling of alkylzinc halides with α-chloroketones catalyzed by Cu(acac)2 is described. Using this method, primary and secondary alkyl groups are introduced adjacent to a ketone carbonyl under mild reaction conditions and in good yield. Cyclic, acyclic, aromatic, and aliphatic α-chloroketones are suitable substrates. Optically active α-chloroketones are converted to optically active products. The reaction was found to proceed stereospecifically with inversion of stereochemistry. The reaction is proposed to occur by direct substitution of the chloride with the alkyl group of an organocopper, -magnesium, or -zinc species. Copyright