151813-47-7Relevant articles and documents
Dynamic Kinetic Resolution of Aldehydes by Hydroacylation
Chen, Zhiwei,Aota, Yusuke,Nguyen, Hillary M. H.,Dong, Vy M.
, p. 4705 - 4709 (2019)
We report a dynamic kinetic resolution (DKR) of chiral 4-pentenals by olefin hydroacylation. A primary amine racemizes the aldehyde substrate via enamine formation and hydrolysis. Then, a cationic rhodium catalyst promotes hydroacylation to generate α,γ-disubstituted cyclopentanones with high enantio- and diastereoselectivities.