151921-25-4

Basic information

• Product Name: 1-furfurylidene-4-(N-antipyrinylglycyl)-3-thiosemicarbazone
• CAS NO: 151921-25-4
• Molecular Weight: 412.472
• Mol File: 151921-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-furfurylidene-4-(N-antipyrinylglycyl)-3-thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-furfurylidene-4-(N-antipyrinylglycyl)-3-thiosemicarbazone(151921-25-4)
• EPA Substance Registry System: 1-furfurylidene-4-(N-antipyrinylglycyl)-3-thiosemicarbazone(151921-25-4)

Safety Data

• Hazardous Substances Data: 151921-25-4(Hazardous Substances Data)

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 5419-96-5 furan-2-aldehyde thiosemicarbazone 
• 70862-67-8 ethyl-2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)acetate 

Relevant articles and documents

Antipyrine congeners as antidepressant agents

1-(N-Antipyrinylglycyl)-3-arylideneamino)-2-thiobarbituric acids (III) were synthesized from 1-arylidene-4-(N-antipyrinyl glycyl)-3-thiosemicarbazones (II). Compounds II in turn were prepared from 4-amino antipyrine. Compounds III were finally converted into 1-(N-antipyrinylglycyl)-3-[(3'-chloro-4-aryl) azitidinyl]-2-thiobarbituric acids (IV). 4-Aminoantipyrine was also treated with different N-protected amino acids in the presence of N,N'-dicyclohexylcarbodiimide to yield N-(antipyrinylcarbamoyl) substituted alkyl benzamides (V); their debenzoylation yielded 2-(amino-N-antipyrinyl) substituted acetamides (VI). The compounds were screened for their antidepressant activity. Compounds IIId, Va and Vb exhibited activity better than imipramine with less toxicity (ALD50 > 1000 mg/kg).