152-43-2 Usage
Description
Quinestrol, a synthetic estrogen, is a 3-cyclopentyl ether of ethynyl estradiol. It is effective in hormone replacement therapy and is known for its estrogen-like properties. After gastrointestinal absorption, Quinestrol is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol.
Uses
Used in Hormone Replacement Therapy:
Quinestrol is used as a hormone replacement agent for addressing various symptoms and conditions related to estrogen deficiency, such as menopausal symptoms and osteoporosis prevention.
Used in Postpartum Lactation Suppression:
Quinestrol is used as an agent for suppressing lactation in postpartum women, although its application in this context is limited and requires further study.
Used in Contraceptive Therapy:
In combination with synthetic progestogens, Quinestrol is used as a contraceptive agent. However, additional research is needed to fully understand its effectiveness and safety in this application.
Used in Pharmaceutical Industry:
Quinestrol is used as an isoleucyl-tRNA synthetase inhibitor, which has potential applications in the development of new drugs targeting specific enzymes.
Used in Antimicrobial Applications:
Quinestrol has antibacterial and antimycoplasmal properties, making it useful in the development of treatments for various bacterial and mycoplasma infections.
references
[1]. baumgardner sb, condrea h, daane ta, et al. replacement estrogen therapy for menopausal vasomotor flushes. comparison of quinestrol and conjugated estrogens. obstet gynecol. 1978 apr;51(4):445-52.[2]. skouby, s.o. criteria for the selection of an optimal estrogen replacement. gynecological endocrinology 15, 60-67 (2001).[3]. li j, chen f, li c,et al. quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. tissue cell. 2014 oct;46(5):318-25.[4]. li j, chen f, chen y, et al. mitochondrial- and fas-l-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. toxicol mech methods. 2014 dec;24(9):609-15.
Check Digit Verification of cas no
The CAS Registry Mumber 152-43-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 152-43:
(5*1)+(4*5)+(3*2)+(2*4)+(1*3)=42
42 % 10 = 2
So 152-43-2 is a valid CAS Registry Number.
InChI:InChI=1/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1
152-43-2Relevant articles and documents
Eco-friendly synthesis of 3-etherified estrones
Zheng, Dong-Qing,Jing, Yu,Zheng, Bing-Ying,Ye, Yun-Fei,Xu, Sheng,Tian, Wei-Sheng,Ma, Hai-Yan,Ding, Kai
, p. 2164 - 2169 (2016/04/09)
The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.