152-74-9

Basic information

• Product Name: 4,5,6,7-Tetrachloro-3,6-dihydroxy-2,4,5,7-tetraiodospiro(isobenzofuran-1(3H),9(9H)-xanthen)-3-one
• CAS NO: 152-74-9
• Molecular Formula: C₂₀H₄Cl₄I₄O₅
• Molecular Weight: 973.679
• Mol File: 152-74-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 741.8°Cat760mmHg
• Flash Point: 402.4°C
• Density: 2.96g/cm³
• CAS DataBase Reference: 4,5,6,7-Tetrachloro-3,6-dihydroxy-2,4,5,7-tetraiodospiro(isobenzofuran-1(3H),9(9H)-xanthen)-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-Tetrachloro-3,6-dihydroxy-2,4,5,7-tetraiodospiro(isobenzofuran-1(3H),9(9H)-xanthen)-3-one(152-74-9)
• EPA Substance Registry System: 4,5,6,7-Tetrachloro-3,6-dihydroxy-2,4,5,7-tetraiodospiro(isobenzofuran-1(3H),9(9H)-xanthen)-3-one(152-74-9)

Safety Data

• Hazardous Substances Data: 152-74-9(Hazardous Substances Data)

Upstream product

• 13245-63-1 3',4',5',6'-tetrachlorofluorescein 

Downstream Products

• 88157-10-2 ethyl 4,5,6,7-tetrachloro-7a-(6'-hydroxy-2',4',5',7'-tetraiodo-3'-oxo-3H-xanthen-9'-yl)benzoate 
• 1207326-22-4 2,3,4,5-tetrachloro-6-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-benzoic acid 5-(3-tert-butoxycarbonylaminopropyl-carbamoyl)pentyl ester 
• 106805-54-3 2,3,4,5-Tetrachloro-6-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-benzoic acid 5-carboxy-pentyl ester 

Relevant articles and documents

Rose Bengal analogs and vesicular glutamate transporters (VGLUTs)

Vesicular glutamate transporters (VGLUTs) allow the loading of presynaptic glutamate vesicles and thus play a critical role in glutamatergic synaptic transmission. Rose Bengal (RB) is the most potent known VGLUT inhibitor (K i 25 nM); therefore we designed, synthesized and tested in brain preparations, a series of analogs based on this scaffold. We showed that among the two tautomers of RB, the carboxylic and not the lactonic form is active against VGLUTs and generated a pharmacophore model to determine the minimal structure requirements. We also tested RB specificity in other neurotransmitter uptake systems. RB proved to potently inhibit VMAT (Ki 64 nM) but weakly VACHT (Ki >9.7 μM) and may be a useful tool in glutamate/acetylcholine co-transmission studies.