1520094-30-7Relevant articles and documents
Stereoselective Titanium-mediated Aldol reactions of a chiral lactate-derived Ethyl Ketone with Ketones
Alcoberro, Sandra,Gómez-Palomino, Alejandro,Solà, Ricard,Romea, Pedro,Urpí, Fèlix,Font-Bardia, Mercè
supporting information, p. 584 - 587 (2014/04/03)
Aldol reactions of titanium enolates of lactate-derived ethyl ketone 1 with other ketones proceed in a very efficient and stereocontrolled manner provided that a further equivalent of TiCl4 is added to the reacting mixture. The scope of these reactions encompasses simple ketones such as acetone or cyclohexanone as well as other ketones that contain potential chelating groups such as pyruvate esters or α- and β-hydroxy ketones.