152074-06-1

Basic information

• Product Name: 2-Bromo-1-(3-ethyl-phenyl)-ethanone
• Synonyms: 2-Bromo-1-(3-ethyl-phenyl)-ethanone;Ethanone, 2-bromo-1-(3-ethylphenyl)-
• CAS NO: 152074-06-1
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.09774
• Mol File: 152074-06-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 286.5±23.0 °C(Predicted)
• Appearance: /
• Density: 1.360±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Bromo-1-(3-ethyl-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1-(3-ethyl-phenyl)-ethanone(152074-06-1)
• EPA Substance Registry System: 2-Bromo-1-(3-ethyl-phenyl)-ethanone(152074-06-1)

Safety Data

• Hazardous Substances Data: 152074-06-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-(3-ethyl-phenyl)-ethanone is a chemical compound with the molecular formula C10H11BrO. It is a derivative of ethanone and contains a bromine atom. The compound is also referred to as 3-Ethylphenacyl bromide. It is commonly used in organic synthesis as a building block in the production of various pharmaceuticals and agrochemicals. This chemical is known for its potential as a reagent in Friedel-Crafts acylation reactions, which are important in the synthesis of aromatic ketones. Additionally, 2-Bromo-1-(3-ethyl-phenyl)-ethanone exhibits biological activity and has been studied for its potential as an antifungal agent. Overall, this compound is a versatile chemical with applications in both research and industry.

Upstream product

• 22699-70-3 3-ethylacetophenone 

Downstream Products

• 1350516-03-8 2-(4-ethylphenyl)quinoxaline 

Relevant articles and documents

Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Qo binding site of cytochrome bc1.

ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES

The present invention relates to anilinopyrazole compounds of formula (1) in which R3 represents an aromatic 5- or 6-membered heteroaromatic ring which is optionally fused to phenyl, said heterocycle or fused heterocycle is optionally substituted, X represents a carboxylic acid, ester or amide, or sulfonamide, and the remaining groups are as defined in the text. It also relates to pharmaceutical compositions containing these materials and, and methods for treating diabetes and related disorders using these materials.

Diaminothiazoles having antiproliferative activity

Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.