152121-44-3

Basic information

• Product Name: 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine
• Synonyms: 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine;4-[5-(4-Fluorophenyl)-2-[4-(Methylthio)phenyl]-1H-iMidazol-4-yl]pyridine;4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-3H-imidazol-4-yl]-pyridine
• CAS NO: 152121-44-3
• Molecular Formula: C₂₁H₁₆FN₃S
• Molecular Weight: 361.4352432
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates;Sulfur & Selenium Compounds;Aromatics, Heterocycles, Inhibitors, Intermediates, Sulfur & Selenium Compounds
• Mol File: 152121-44-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 220-222°C
• Boiling Point: 560.875°C at 760 mmHg
• Flash Point: 293.007°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: Refrigerator
• Solubility: Acetone, DMSO, Methanol
• CAS DataBase Reference: 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine(152121-44-3)
• EPA Substance Registry System: 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine(152121-44-3)

Safety Data

• Hazardous Substances Data: 152121-44-3(Hazardous Substances Data)

Usage

Description

4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine is a complex organic compound characterized by its unique molecular structure. It is a yellow solid with potential applications in the pharmaceutical industry due to its ability to act as an inhibitor of glucagon receptors and its use in the synthesis of p38 MAP kinase inhibitors.

Uses

Used in Pharmaceutical Industry:
4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine is used as a potential inhibitor of glucagon receptors for the development of treatments targeting metabolic disorders and conditions related to glucagon dysregulation.
Additionally, 4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine is used in the synthesis of p38 MAP kinase inhibitors, which are important in the development of therapeutics for various diseases, including inflammatory and autoimmune conditions, as well as certain types of cancer.
Chemical Properties:
4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine is a yellow solid, which indicates its stability and potential for use in various chemical reactions and formulations.

InChI:InChI=1/C21H16FN3S/c1-26-18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 152122-41-3 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 117423-41-3 4-((tert-butyldimethylsilyloxy)methyl)pyridine 
• 586-95-8 pyridine-4-methanol 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 152121-47-6 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine 

Relevant articles and documents

Treatment for CNS injuries

The present invention is directed to the use of 2,4,5-trisubstituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.

Substituted imidazoles as glucagon receptor antagonists

A modestly active, nonselective triarylimidazole lead was optimized for binding affinity with the human glucagon receptor. This led to the identification of a 2- and/or 4-alkyl or alkyloxy substituent on the imidazole C4-aryl group as a structural determinant for significant enhancement in binding with the glucagon receptor (e.g., 41, IC50 = 0.053 μM) and selectivity (> 1000 ×) over p38 MAP kinase in this class of compounds.

Pyridyl imidazoles

Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.