152146-59-3

Basic information

• Product Name: 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID
• Synonyms: 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID;4-[(2-Butyl-5-forMyl-1H-iMidazol-1-yl)Methyl]benzoic Acid;4-[(2-n-Butyl-5-forMyl-1H-iMidazol-1-yl)Methyl]benzoic Acid;Eprosartan Related CoMpound 2
• CAS NO: 152146-59-3
• Molecular Formula: C₁₆H₁₈N₂O₃
• Molecular Weight: 286.33
• Product Categories: Heterocycles;Impurities;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles, Impurities, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 152146-59-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 147-148 °C
• Boiling Point: 505.272 °C at 760 mmHg
• Flash Point: 259.379 °C
• Appearance: /
• Density: 1.195 g/cm³
• PKA: 4.12±0.10(Predicted)
• CAS DataBase Reference: 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID(152146-59-3)
• EPA Substance Registry System: 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID(152146-59-3)

Safety Data

• Hazardous Substances Data: 152146-59-3(Hazardous Substances Data)

Upstream product

• 56-91-7 p-aminomethylbenzoic acid 
• 57246-71-6 methyl pentanimidate 
• 7440-69-9 bismuth 
• 226068-17-3 4-[(2-butyl-5-hydroxymethyl-1H-imidazo-1-yl)methyl]benzoic acid 
• 7440-06-4 platinum 
• 133040-03-6 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde 
• 149550-85-6 2-butyl-1-<(4-carbomethoxyphenyl)methyl>-5-(hydroxymethyl)imidazole 

Relevant articles and documents

Procedure for producing formyl imidazoles

A new procedure for the catalytic conversion of hydroxy methyl imidazoles to formyl imidazoles is described. The catalysis takes place in the presence of a peroxide. Formyl imidazoles are important intermediate products for pharmaceutical substances.

A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazolecarboxaldehydes ranging from 85:15 to 100: 0. This methodology could be extended with similar results to the synthesis of imidazole-5-nitriles by the reaction of 2-bromo-3-methoxy-2-propenenitrile with N-monosubstituted amidines.