152150-03-3 Usage
General Description
2-(Quinolin-5-Yl)acetic acid, also known as 2-QAA, is a chemical compound with molecular formula C11H9NO2. It is a derivative of quinoline and acetic acid, and is used in pharmaceutical research and development. 2-QAA has shown potential anti-inflammatory and analgesic properties, making it a target for drug discovery and therapeutic applications. Its molecular structure contains a quinoline ring with a carboxylic acid group, and it is known to inhibit the production of pro-inflammatory mediators in the body. 2-(Quinolin-5-Yl)acetic acid has attracted interest in the scientific and medical communities for its potential to treat various inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 152150-03-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,1,5 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 152150-03:
(8*1)+(7*5)+(6*2)+(5*1)+(4*5)+(3*0)+(2*0)+(1*3)=83
83 % 10 = 3
So 152150-03-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO2/c13-11(14)7-8-3-1-5-10-9(8)4-2-6-12-10/h1-6H,7H2,(H,13,14)
152150-03-3Relevant articles and documents
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon,Truong, Anh P.,Neitz, R. Jeffrey,Neitzel, Martin,Probst, Gary D.,Hom, Roy K.,Peterson, Brian,Galemmo Jr., Robert A.,Konradi, Andrei W.,Sham, Hing L.,Tóth, Gergley,Pan, Hu,Yao, Nanhua,Artis, Dean R.,Brigham, Elizabeth F.,Quinn, Kevin P.,Sauer, John-Michael,Powell, Kyle,Ruslim, Lany,Ren, Zhao,Bard, Frédérique,Yednock, Ted A.,Griswold-Prenner, Irene
scheme or table, p. 1838 - 1843 (2011/05/05)
The SAR of a series of tri-substituted thiophene JNK3 inhibitors is described. By optimizing both the N-aryl acetamide region of the inhibitor and the 4-position of the thiophene we obtained single digit nanomolar compounds, such as 47, which demonstrated an in vivo effect on JNK activity when dosed orally in our kainic acid mouse model as measured by phospho-c-jun reduction.
