1522362-09-9

Basic information

• Product Name: tert-butyl 4-(4-(tert-butyl)phenyl)-4-oxobutanoate
• Synonyms: tert-butyl 4-(4-(tert-butyl)phenyl)-4-oxobutanoate
• CAS NO: 1522362-09-9
• Molecular Weight: 290.403
• Mol File: 1522362-09-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(4-(tert-butyl)phenyl)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-(tert-butyl)phenyl)-4-oxobutanoate(1522362-09-9)
• EPA Substance Registry System: tert-butyl 4-(4-(tert-butyl)phenyl)-4-oxobutanoate(1522362-09-9)

Safety Data

• Hazardous Substances Data: 1522362-09-9(Hazardous Substances Data)

Upstream product

• 63488-10-8 4-tert-butylmagnesium bromide 
• 35288-08-5 4-(4-tert-butylphenyl)-4-oxobutyric acid 
• 75-65-0 tert-butyl alcohol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 1746-23-2 4-tert-Butylstyrene 

Relevant articles and documents

Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters

Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification. This strategy is capable of constructing enantioenriched lactams and benzo-lactams of a five-, six-, or seven-membered ring in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodology.