1522364-91-5Relevant articles and documents
Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin
Revankar, Hrishikesh M.,Kulkarni, Manohar V.,Joshi, Shrinivas D.,More, Uttam A.
, p. 750 - 757 (2013/12/04)
Two series of 4-aryloxymethyl coumarins derived from the reaction of 4-bromomethyl coumarins with ethyl gallate and ethyl ester of N-Benzoyl tyrosine have been synthesized. Gallate ethers 3a-3g and tyrosine derivatives 4e-4j were most effective against Entercoccusfaecalis. They were also found to be effective against Aspergillusniger and Candidaalbicans. Comparative docking studies with novobiocin have indicated better binding ability and higher 'C' score values than novobiocin.
