1524-54-5

Basic information

• Product Name: ALLYL 2,2,2-TRIFLUOROETHYL ETHER
• Synonyms: 2,2,2-trifluoroethylallylether;3-(2,2,2-trifluoroethoxy)-1-propen;ether,allyl2,2,2-trifluoroethyl;ALLYL 2,2,2-TRIFLUOROETHYL ETHER;1,1,1-TRIFLUORO-3-OXA-5-HEXENE
• CAS NO: 1524-54-5
• Molecular Formula: C₅H₇F₃O
• Molecular Weight: 140.1
• Mol File: 1524-54-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 54-59
• Flash Point: 4.5°C
• Appearance: /
• Density: 1.086g/cm³
• Vapor Pressure: 115mmHg at 25°C
• Refractive Index: 1.341
• CAS DataBase Reference: ALLYL 2,2,2-TRIFLUOROETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: ALLYL 2,2,2-TRIFLUOROETHYL ETHER(1524-54-5)
• EPA Substance Registry System: ALLYL 2,2,2-TRIFLUOROETHYL ETHER(1524-54-5)

Safety Data

• Hazard Codes: F,Xi
• Statements: 10
• Safety Statements: 16-23-36
• RIDADR: 3271
• HazardClass: IRRITANT, FLAMMABLE
• Hazardous Substances Data: 1524-54-5(Hazardous Substances Data)

Usage

Description

ALLYL 2,2,2-TRIFLUOROETHYL ETHER is an organic compound that serves as a versatile intermediate in the synthesis of various chemical compounds, particularly in the preparation of analogs of cyclitols and sugars, as well as heteroaryl substituted propan-2-ols.

Uses

Used in Pharmaceutical Industry:
ALLYL 2,2,2-TRIFLUOROETHYL ETHER is used as a synthetic intermediate for the preparation of cyclitol and sugar analogs, which are essential in the development of pharmaceutical compounds with potential therapeutic applications.
Used in Enzyme Inhibitor Development:
ALLYL 2,2,2-TRIFLUOROETHYL ETHER is used as a synthetic intermediate for the preparation of heteroaryl substituted propan-2-ols, which act as metalloenzyme inhibitors. These inhibitors are useful in the treatment of metalloenzyme-mediated diseases, offering potential therapeutic benefits in various medical conditions.

InChI:InChI=1/C5H7F3O/c1-2-3-9-4-5(6,7)8/h2H,1,3-4H2

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 107-05-1 3-chloroprop-1-ene 
• 7575-57-7 allyl benzenesulfonate 
• 4873-09-0 allyl tosylate 
• 6165-74-8 4-Chlor-benzolsulfonsaeure-allylester 
• 20443-61-2 m-Nitro-benzol-sulfonsaeure-allylester 
• 33420-11-0 allyl-4-nitrophenylsulfonate 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 107-18-6 allyl alcohol 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 106-95-6 allyl bromide 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 660-23-1 dichloromethyl[3-(2,2,2-trifluoroethoxy)propyl]silane 
• 803730-99-6 (E)-5,5-Difluoro-3-hydroxy-1-phenyl-octa-1,7-dien-4-one 
• 1287686-71-8 C₁₂H₁₃F₃N₂O₂ 
• 1287686-60-5 C₂₀H₁₆F₅N₃O₄ 

Relevant articles and documents

Preparation and characterization of nonpolar fluorinated carbosilane dendrimers by APcI mass spectrometry and small-angle X-ray scattering

The following highly fluorinated nonpolar dendrimers were obtained in high yields from multiple hydrosilylation reactions between core hydride terminated carbosilane dendrimers and allyl-1,1-dihydrotrifluoroethyl ether or allyl-1,1-dihydroheptadecafluorononyl ether through divergent synthetic routes: Si[CH2-CH2SiMe2(CH2CH 2CH2OCH2CF3)]4 (7), Si{CH2CH2SiMe[CH2CH2SiMe(CH 2CH2CH2OCH2CF3) 2]2}4 (8), Si[CH2CH2Si(CH2CH2CH 2OCH2C8F17)3]4 (9), Si[CH2CH2SiMe2(CH2CH 2CH2OCH2C8F17)] 4 (10), and Si{CH2-CH2Si[CH2CH2Si(CH 2CH2CH2OCH2C8F 17)3]3}4 (11). These compounds were characterized by elemental and spectroscopic analyses. Valuable mass spectral data were obtained by using atmospheric pressure chemical ionization (APcI). The fluorinated dendrimer molecule and the nonfluorinated core scatter X-ray light differently and present unique slopes on the Guinier Plot of data from small-angle X-ray light scattering (SAXS) in hexafluorobenzene. Glass transition temperatures (Tg) and thermogravimetric analyses (TGA) of the dendrimers were determined.

A direct and rapid route to α,α-difluoroacylsilanes from trifluoroethanol

α,α-Difluoroacylsilanes were synthesised directly from a range of allyl ethers of trifluoroethanol via dehydrofluorination/metallation procedures, followed by thermal [3,3]-sigmatropic rearrangement of the intermediate vinylmetals. The scope and limitatio

A potentially divergent and rapid route to analogues of deoxycyclitols, pentopyranoses, 6-deoxyhexoses, and hexoses

(Chemical Equation Presented) Direct precursors to analogues of pentopyranoses, 6-deoxyhexoses, and hexoses, in which a CF2 center replaces the pyranose oxygen, have been synthesized rapidly from trifluoroethanol. A simple scaleable allylation