1524-86-3

Basic information

• Product Name: 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone
• Synonyms: 9-fluoro-11b,21-dihydroxy-16a,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione;9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone;9-fluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione;9α-FLUORO-11β,16α,17α,21-TETRAHYDROXY-PREGNA-4-ENE-3,20-DIONECYCLIC16,17-ACETAL;9-Fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione;9-Fluoro-16α,17-(isopropylidenedioxy) Corticosterone;9-fluoro-11β,21-dihydroxy-16α,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione;HydrotriaMcinolone Acetate
• CAS NO: 1524-86-3
• Molecular Formula: C₂₄H₃₃FO₆
• Molecular Weight: 436.51
• EINECS: 216-195-2
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 1524-86-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 575.7 °C at 760 mmHg
• Flash Point: 302 °C
• Appearance: /
• Density: 1.31 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone(1524-86-3)
• EPA Substance Registry System: 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone(1524-86-3)

Safety Data

• Hazardous Substances Data: 1524-86-3(Hazardous Substances Data)

Usage

Description

9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone, also known as Triamcinolone Acetonide EP Impurity E, is a synthetic fluorinated corticosteroid. It is characterized by its pale yellow solid appearance and has been tested for its potential in inhibiting granuloma in rats and for vasoconstriction activity in human subjects.

Uses

Used in Pharmaceutical Industry:
9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone is used as a potential topical anti-inflammatory agent for its ability to inhibit inflammation and reduce swelling. Its corticosteroid properties make it a candidate for treating various skin conditions and inflammatory disorders.
Used in Research and Development:
In the field of medical research, 9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone is utilized for studying its effects on granuloma inhibition and vasoconstriction. This helps in understanding the compound's potential applications in developing new treatments for related health issues.
Used in Veterinary Medicine:
9-Fluoro-16a,17-(isopropylidenedioxy)corticosterone may also find applications in veterinary medicine, particularly for the treatment of inflammation and related conditions in animals, given its demonstrated effectiveness in inhibiting granuloma in rats.

Upstream product

• 337-02-0 9α-fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione 
• 160512-81-2 9β,11β-epoxy-21-hydroxy-16α,17-(isopropylidenedioxy)pregn-4-ene-3,30-dione 
• 160512-79-8 9-bromo-11β-hydroxy-16α,17-(isopropylidenedioxy)-3,20-dioxopregn-4-en-21-yl formate 
• 98422-57-2 16α,21-diacetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione 
• 426-39-1 16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxpregn-4-ene-3,20-dione 
• 23460-76-6 21-acetoxy-pregna-4,9⁽¹¹⁾,16-triene-3,20-dinone 
• 74220-43-2 21-Acetoxy-16α,17α-dihydroxy-4,9(11)-pregnadien-3,20-dion 
• 91160-85-9 16α,21-diacetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 98632-54-3 16α,21-diacetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione 
• 67-64-1 acetone 
• 50-03-3 hydrocortisone acetate 

Downstream Products

• 76-25-5 triamcinolone acetonide 
• 1181-32-4 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione 
• 3093-35-4 halcinonide 

Relevant articles and documents

Synthesis of triamcinolone acetonide from 9-hydroxy-3-methoxy-17-(2-methoxy-3-oxazolin-4-yl)androsta-3,5,16-trie ne

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Preparation process of halcinonide intermediate

The invention provides a prepration process of a halcinonide intermediate. The preparation process comprises the steps: taking a hydrofluoric acid-acetone mixed solvent as a solvent, slowly adding an intermediate N-3 at subzero 40 DEG C to subzero 30 DEG C, carrying out reaction for 4 to 8 hours after material feeding is completed, enabling the temperature to return to subzero 5 DEG C to 0 DEG C, continuously carrying out reaction for 10 to 30 min, slowly adding reaction fluid into a potassium carbonate solution after the reaction is completed, adjusting the PH value to 7.0 to 7.5, filtering and discharging a product, and drying the product to obtain the halcinonide intermediate with the structure as shown in formula N-5. According to the preparation process, a one-pot method is adopted for production, so that the production steps are effectively simplified, and the production period is shortened; the preparation process is more environment-friendly.

STEROID ESTERS

Compounds of the general formula (I), in which formula the 1,2-position is saturated or is a double bond, R1 is hydrogen or a straight or branched hydrocarbon chain, R2 is hydrogen or a straight or branched hydrocarbon chain, R3 is acyl, X1 is hydrogen or halogen, X2 is hydrogen or halogen and provided that 1) R1 and R2 are not simultaneously hydrogen, 2) X1 and X2 are not simultaneously hydrogen, 3) when the 1,2-position is a double bond, R1 and R2 are not simultaneously methyl groups, 4) when the 1,2-position is a double, R1 is a hydrogen atom and R2 is a straight or branched hydrocarbon chain having 1-10 carbon atoms R3 is acyl having 11-20 carbon atoms, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment of inflammatory and allergic conditions