152433-65-3

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 5-ethyl-6-(phenylthio)-
• CAS NO: 152433-65-3
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 248.305
• Mol File: 152433-65-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 5-ethyl-6-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 5-ethyl-6-(phenylthio)-(152433-65-3)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5-ethyl-6-(phenylthio)-(152433-65-3)

Safety Data

• Hazardous Substances Data: 152433-65-3(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 20295-24-3 5-ethyl-6-chloro-2,4-pyrimidinedione 
• 120268-44-2 5-ethyl-6-chloro-2,4-dimethoxypyrimidine 
• 2518-72-1 5-ethyl barbituric acid 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 882-33-7 diphenyldisulfane 
• 189637-62-5 5-Ethyl-2,4-dimethoxy-6-phenylsulfanyl-pyrimidine 

Downstream Products

• 195720-15-1 1-[(Cyclopent-1-en-1-yl)methyl]-5-ethyl-6-phenylthio-2,4-pyrimidinedione 

Relevant articles and documents

Synthesis of certain 6-(arylthio)uracils as potential antiviral agents

A series of 6-(Arylthio)uracils have been prepared via condensation of 6-chlorouracil or 5-ethyl-6-chlorouracil with the corresponding thiopnenol derivatives in pyridine or ethanolic potassium hydroxide. The synthesized compounds were tested for their antiviral activity. Some of the 5-ethyl-6-(arylthio)uracil derivatives 10a-g showed moderate activities against hepatitis B Virus (HBV) and HIV-1 virus.

Antiviral 2, 4-pyrimidinedione derivatives

Novel 2,4-pyrimidinedione compounds, and pharmaceutically acceptable salts thereof which possess good antiviral activities, and specifically represented by the following formula(I): STR1 wherein: R 1 represents an unsubstituted or substituted allyl group represented by CH 2 CH CR 5 R 6 or an unsubstituted or substituted propargyl group represented by CH 2 C CR 7 wherein R 5, R 6 and R 7 are each independently a hydrogen atom; a methyl group optionally substituted with a halogen atom, or a C 1-10 carbonyloxy, hydroxy, azido, cyano, optionally substituted amino, optionally substituted phosphonyl, optionally substituted phenyl, C 3-10 heteroaryl, C 1-3 alkoxy or benzyloxy radical; a C 2-10 alkyl or alkenyl group; a cyclopropyl group; an optionally substituted phenyl group; a C 3-10 heteroaryl group; a C 1-10 ester group; or an optionally substituted C 1-10 alkylamide group;R 2 represents a halogen atom, an optionally substituted C 1-5 alkyl, C 3-6 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl group or a benzyl group;R 3 and R 4 represent independently a hydrogen or halogen atom, or a hydroxy, C 1-3 alkyl, fluoromethyl, C 1-3 alkoxy, amino, C 2-6 alkylester or C 2-7 alkylamide group;A represents an oxygen or sulfur atom;Z represents an oxygen or sulfur atom; a carbonyl group; an amino group; or a methylene group optionally substituted with at least one selected from the group consisting of a halogen atom, and a cyano, hydroxy, azido, amino, C 1-3 alkylamide, C 1-4 ester, and nitro groups.