152743-19-6 Usage
Description
Lysionotin, also known as Chinese stone Chlorophytum, is the whole herb of Lysionotus pauciflorus Maxim, which belongs to the Gesneriaceae family. It is a small evergreen shrub that grows in wet places of rock slopes and clings to stones or trees. Lysionotin is characterized by its yellow needle crystal or light yellow powder appearance, odorless and tasteless properties, and a melting point of 197–199 °C. It is slightly soluble in chloroform and in methanol, ethanol, or ethyl acetate, very slightly soluble in ether, insoluble in water, and soluble in 5% sodium carbonate solution, potassium hydroxide, or sodium hydroxide solution.
Uses
Used in Traditional Medicine:
Lysionotin is used as a medicinal herb for various applications, including eliminating sputum and poison, promoting digestion, nourishing blood, and curing rheumatism, emphysema, dizziness, and various kinds of deficiency. It is also used to treat hematemesis, blood vomiting, pain of waist and knee, and contusions.
Used in Herbal Formulas:
Lysionotin is used as an ingredient in herbal formulas to clear the lung to relieve cough, cool blood, and promote hemostasis.
Used in Pharmaceutical Industry:
Lysionotin's unique properties, such as its solubility in certain solutions and its tasteless and odorless characteristics, make it a potential candidate for further research and development in the pharmaceutical industry for various applications.
History
Stone Chlorophytum is the folk antituberculous herb, the fat-soluble component
separated from which is lysionotin. China’s scientists for the first time found that
lysionotin is the effective component of the antituberculosis in stone
Chlorophytum. Xu Yin et al., who worked in Shanghai Institute of Materia
Medica, Chinese Academy of Sciences, found that lysionotin is 5,7-dihydroxy 4′,6′,8-trimethoxy flavonoids by structure identification, which is the known
compound nevadensin Farkas et al. used a 14-step synthesis to demonstrate the structure of nevadensin
with complex reaction steps. The synthesis route was simpler, which was designed
by Tang Cheng-fang in Shanghai Institute of Materia Medica, Chinese Academy of
Sciences, and the total yield was ten times higher .
oluble, clinical use of injection caused pain to the patients. In order to overcome the
above shortcomings, methylamine glucoside salt of nevadensin was synthesized for
intramuscular injection. The effect is significant without causing pain. In order to
explore its structure-activity relationship, seven chemical analogues were designed
and synthesized with good activity in antibacterial test of Mycobacterium tuberculo sis, which include 6,8-dichloro-4′-methoxyflavone, 6,7-dimethyl-4′-methoxyflavone,
6,7-dichloro-4′-methoxyflavone, dimethoxy-3′, 4′-dimethoxyflavone,
6,7-dichloro-3′, 4′-dimethoxyflavone, 6-chloro-4′-methoxyflavone, and 4-dichloro 6-(4-methoxybenzoyloxy) acetophenone (Fig. 3)
Indications
It can make expectoration easy, relieve a cough, soften hard lumps, and dispel nodes. It is used clinically for bronchitis, lymph node tuberculosis, chill cold, etc
Pharmacology
Anti-Mycobacterium tuberculosis, Anti-inflammatory EffectNevadensin 200 μg/ml in vitro has obvious anti-Mycobacterium tuberculosis
effect; in vivo test also has a protective effect. The treatment for lymph node is sig nificant . Nevadensin has significant inhibitory effect on the experimental arthri tis caused by serotonin, formaldehyde, and kaolin. It also has an inhibitory effect on
the cotton ball granuloma. Furthermore, the anti-inflammatory effect does not
depend on the presence of adrenal cortex Antihypertensive EffectThe main role of nevadensin in the central nervous system causes blood pressure
reduction, which also has an impact on the peripheral nervous system. Lateral
ventricle injection of nevadensin could reduce arterial blood pressure, and the effect
of lowering systolic blood pressure was stronger than that of reducing diastolic
blood pressure. The mechanism might be that the action of nevadensin on
α-adrenergic receptor is stronger than that of the central β-adrenergic receptor.Scavenging Free RadicalsPhenolic hydroxyl group of nevadensin is the main active group that scavenges
free radicals (OH).
Clinical Use
Nevadensin has been used for the adjuvant therapy of cervical lymph node tuberculosis, tuberculosis, bone tuberculosis, and bronchitis treatment. Adverse reactions were mainly nausea, vomiting, diarrhea and abdominal discomfort, etc
Check Digit Verification of cas no
The CAS Registry Mumber 152743-19-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,7,4 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 152743-19:
(8*1)+(7*5)+(6*2)+(5*7)+(4*4)+(3*3)+(2*1)+(1*9)=126
126 % 10 = 6
So 152743-19-6 is a valid CAS Registry Number.
