152751-57-0 Usage
Description
Sevelamer hydrochloride, also known as Renagel, is a noncalcemic phosphate binder used in the medical field. It is a synthetic polymer that functions to bind and remove excess phosphate from the body, thus helping to maintain phosphorus balance.
Uses
Used in Pharmaceutical Industry:
Sevelamer hydrochloride is used as a noncalcemic phosphate binder for the treatment of hyperphosphatemia in patients with chronic renal failure or chronic kidney disease. It helps to lower the levels of phosphate in the blood, which can accumulate due to impaired kidney function and lead to various complications.
Used in Chronic Kidney Disease Management:
Sevelamer hydrochloride is used as a treatment option for hyperphosphataemia in patients suffering from chronic kidney disease. By binding to dietary phosphate and promoting its excretion through the gastrointestinal tract, it helps to prevent the complications associated with high phosphate levels, such as bone disorders and cardiovascular issues.
Used in Renal Failure Treatment:
Sevelamer hydrochloride is used as a noncalcemic phosphate binder for the treatment of hyperphosphatemia in patients with chronic renal failure. It is an essential component of the management plan for these patients, as it helps to control the phosphate levels and reduce the risk of further health complications.
Originator
Renagel,Chugai Pharmaceutical
Manufacturing Process
Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w,
208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h
and filtered to a 2500 L reactor. The transfer line was rinsed with water (217
kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C
and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for
1.5 h and then heated to reflux for 16 h. The resulting product slurry may be
isolated and washed in decanter centrifuge.
Therapeutic Function
Antihyperphosphatemic
Veterinary Drugs and Treatments
Sevalamer may be useful for treating hyperphosphatemia associated
with chronic renal failure, particularly when oral aluminum
salts are not tolerated.
Check Digit Verification of cas no
The CAS Registry Mumber 152751-57-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,7,5 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 152751-57:
(8*1)+(7*5)+(6*2)+(5*7)+(4*5)+(3*1)+(2*5)+(1*7)=130
130 % 10 = 0
So 152751-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5ClO.C3H7N/c4-1-3-2-5-3;1-2-3-4/h3H,1-2H2;2H,1,3-4H2
