152764-26-6 Usage
Description
6-HydroxyMethyl ExeMestane, a potential metabolite of Exemestane (E957000), is an off-white to pale yellow solid with unique chemical properties. It is derived from the parent compound Exemestane, which is an aromatase inhibitor used in the treatment of hormone receptor-positive breast cancer. The presence of a hydroxymethyl group in its structure distinguishes it from the parent compound, potentially offering different pharmacological properties and applications.
Uses
Used in Pharmaceutical Industry:
6-HydroxyMethyl ExeMestane is used as a pharmaceutical compound for its potential therapeutic applications. As a metabolite of Exemestane, it may exhibit similar or enhanced effects in the treatment of hormone receptor-positive breast cancer. Further research and development are required to explore its full potential in this field.
Used in Research and Development:
6-HydroxyMethyl ExeMestane serves as a valuable compound in the research and development of new drugs and therapies. Its unique chemical properties and relationship to Exemestane make it an interesting candidate for studying the mechanisms of aromatase inhibition and the development of novel treatments for hormone-related cancers and other conditions.
Used in Drug Metabolism Studies:
6-HydroxyMethyl ExeMestane is used as a subject in drug metabolism studies to understand how the body processes and eliminates Exemestane. This knowledge can help researchers optimize drug dosages, minimize side effects, and improve the overall efficacy of Exemestane-based treatments.
Used in Drug Delivery Systems:
Similar to Gallotannin, 6-HydroxyMethyl ExeMestane may benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Researchers can explore the use of various organic and metallic nanoparticles as carriers for this compound, aiming to improve its overall effectiveness in targeted applications.
Check Digit Verification of cas no
The CAS Registry Mumber 152764-26-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,7,6 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 152764-26:
(8*1)+(7*5)+(6*2)+(5*7)+(4*6)+(3*4)+(2*2)+(1*6)=136
136 % 10 = 6
So 152764-26-6 is a valid CAS Registry Number.
152764-26-6Relevant articles and documents
Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)
Buzzetti,Di Salle,Longo,Briatico
, p. 527 - 532 (2007/10/02)
Exemestane (6-methylenandrosta-1,4-diene-3,17-dione; FCE 24304) is an orally active irreversible aromatase inhibitor which is in phase II clinical evaluation for the potential therapy of postmenopausal breast cancer. A series of exemestane analogs, with modifications at the 6-methylene group and with additional reduction at the 17-keto group, were synthesized as potential metabolites and tested in vitro for their effect on human placental aromatase. All these new analogs were found to be less potent in inhibiting aromatase than exemestane. The most effective compound was the 17β-hydroxy- derivative (compound 2), which is 2.6-fold less potent than exemestane [50% inhibitory concentration (IC50) 69 and 27 nM, respectively]. The various C- 6 modified derivatives of the 17-oxo series were found to inhibit the aromatase enzyme in the following descending order: 6-methylene (exemestane) > 6-spirooxirane (6) > 6β-hydroxymethyl (11) > 6-hydroxymethyl (7) > 6β- carboxy (13), showing IC50 values of 27, 206, 295, 2,300, and 7,200 nM, respectively. The 17β-hydroxy analogs of some of the above mentioned compounds were also synthesized (3, 4, 12) and found to be 3-8-fold less potent than the corresponding 17-keto analogs.
