152833-01-7Relevant articles and documents
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase
Chae,McDougall,Dolan,Swenn,Pegg,Moschel
, p. 342 - 347 (1994)
Several new O6-benzylguanine analogs bearing increasingly bulky substituent groups on the benzene ring or at position 9 were tested for their ability to inactivate the human DNA repair protein, O6-alkylguanine-DNA alkyltransferase. S
Convenient synthesis of 2,9-disubstituted guanines mediated by solid- supported reagents
McComas, Warren,Chen, Li,Kim, Kyungjin
, p. 3573 - 3576 (2007/10/03)
A novel application has been developed to separate regioisomers chemoselectively using a solid-supported reagent. An N7/N9 purine regioisomer mixture was purified using aluminum oxide/H+ to provide the N9 isomer selectively as a parallel or high-throughput format (chemoselective high- throughput purification). 2,9-Disubstituted guanines were conveniently prepared by this new method in conjunction with solid-supported reagents. (C) 2000 Elsevier Science Ltd.