152873-41-1

Basic information

• Product Name: C₄₉H₅₀N₈O₁₀S
• CAS NO: 152873-41-1
• Molecular Weight: 943.05
• Mol File: 152873-41-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₉H₅₀N₈O₁₀S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₉H₅₀N₈O₁₀S(152873-41-1)
• EPA Substance Registry System: C₄₉H₅₀N₈O₁₀S(152873-41-1)

Safety Data

• Hazardous Substances Data: 152873-41-1(Hazardous Substances Data)

Upstream product

• 148854-69-7 1-Benzothiazol-2-yl-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-methyl-isothiourea 
• 25152-20-9 5'-amino-5'-deoxythymidine 
• 76423-99-9 dimethyl N-(1,3-benzothiazol-2-yl) dithio imidocarbonate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 148854-79-9 N'-(benzothiazol-2-yl)-N-(3'-deoxythymidin-3'-yl)-N''-(5'-deoxythymidin-5'-yl)guanidine 

Relevant articles and documents

Synthesis, Enzymatic Stability and Base-pairing Properties of Oligothymidylates Containing Thymidine Dimers with Different N-Substituted Guanidine Linkages

Reaction of 5'-amino-5'deoxythymidine 1 with different S,S-dimethyl-N-substituted dithiocarbonimidates 2a-j afforded the N-substituted isothioureas 3a-j which, on further reaction with 3'-amino-3'-deoxythymidine 4 in the presence of AgNO3, led to thymidine dimers 5a-j with different N-substituted guanidine linkages.The dimer with a thiourea linkage (compound 9) was also prepared.Dimers 5a-h were incorporated at different positions in oligothymidylates by using phosphoramidite chemistry.Attempts to incorporate compounds 5i,j and 9 led to complex mixtures. 3'-Protected oligonucleotides showed somewhat higher stability to snake venom phosphodiesterase.Melting experiments revealed that the N-methylsulfonyl-substituted guanidine linkage best mimics the natural phosphodiester bridge.The fluorescence properties of oligonucleotides with dimer 5f were studied in view of its potential use as a non-radioactive label for DNA.