15289-17-5

Basic information

• Product Name: 2,4-Pentadienoic acid, 2-mercapto-5-phenyl-
• CAS NO: 15289-17-5
• Molecular Formula: C11H10O2S
• Molecular Weight: 206.265
• Mol File: 15289-17-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-Pentadienoic acid, 2-mercapto-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pentadienoic acid, 2-mercapto-5-phenyl-(15289-17-5)
• EPA Substance Registry System: 2,4-Pentadienoic acid, 2-mercapto-5-phenyl-(15289-17-5)

Safety Data

• Hazardous Substances Data: 15289-17-5(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 310463-02-6 CG-713 

Downstream Products

• 19163-24-7 5-phenyl-2-thiophenecarboxylic acid 
• 14597-62-7 5-phenylthiophene-2-carboxylic acid methyl ester 
• 649569-52-8 2,2'-dithiobis(5-phenyl-2,4-pentadienoic acid) 

Relevant articles and documents

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.