152943-96-9 Usage
Class
Piperazine derivative
Use in Industry
Pharmaceutical and organic synthesis
Structural Features
a. Methoxy group attached to the phenyl ring
b. Methyl group attached to the piperazine ring
Applications
a. Synthesis of various pharmaceuticals
b. Potential medicinal applications due to pharmacological properties
c. Building block in organic chemical synthesis for production of complex compounds
Chemical Properties
a. Basicity due to piperazine ring
b. Reactivity with electrophiles due to methoxy group
c. Steric hindrance due to methyl group on piperazine ring
Physical Properties
a. Solid at room temperature
b. May have low solubility in water
c. Potential for various polymorphic forms
Safety and Handling
a. May require precautions during synthesis and handling
b. Potential for eye and skin irritation
c. Proper disposal and storage required to prevent environmental contamination
Check Digit Verification of cas no
The CAS Registry Mumber 152943-96-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,9,4 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 152943-96:
(8*1)+(7*5)+(6*2)+(5*9)+(4*4)+(3*3)+(2*9)+(1*6)=149
149 % 10 = 9
So 152943-96-9 is a valid CAS Registry Number.
152943-96-9Relevant articles and documents
Identification of novel GLUT inhibitors
Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig
, p. 1732 - 1737 (2016/07/27)
The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.