15295-43-9

Basic information

• Product Name: phenyl(2-phenylcyclopropyl)methanone
• CAS NO: 15295-43-9
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.2818
• Mol File: 15295-43-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 155.1°C
• Density: 1.143g/cm³
• Vapor Pressure: 2.73E-05mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: phenyl(2-phenylcyclopropyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(2-phenylcyclopropyl)methanone(15295-43-9)
• EPA Substance Registry System: phenyl(2-phenylcyclopropyl)methanone(15295-43-9)

Safety Data

• Hazardous Substances Data: 15295-43-9(Hazardous Substances Data)

Usage

General Description

Phenyl(2-phenylcyclopropyl)methanone is a chemical compound containing a phenyl group attached to a cyclopropyl ring and a methanone functional group. It is commonly used in organic synthesis as a building block for creating other complex molecules. phenyl(2-phenylcyclopropyl)methanone is known for its unique structure and reactivity, as the presence of the cyclopropyl ring imparts specific stereochemical properties that can influence the way it interacts with other molecules. Additionally, the phenyl group provides aromatic characteristics that can affect the compound's overall stability and electronic properties. Due to these distinct features, phenyl(2-phenylcyclopropyl)methanone is utilized in a variety of research and industrial applications in the field of organic chemistry.

Upstream product

• 32523-77-6 trans-1-bromo-2-phenylcyclopropane 
• 98-88-4 benzoyl chloride 
• 72174-83-5 1-phenyl-1-(2-phenylcyclopropyl)-N,N-dimethylmethaniminium fluoroborate 
• 90364-78-6 phenyl (2-phenylcyclopropyl)-methanol 
• 620151-96-4 (S)-ethyl N-(2-phenylcyclopropanecarbonyl)-4,4-dimethylpyroglutamate 
• 186581-53-3 diazomethane 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 62668-02-4 (E)-1,3-diphenyl-2-propen-1-ol 
• 1774-47-6 trimethylsulfoxonium iodide 
• 70775-39-2 dimethylsulfoxonium methylide 
• 939-87-7 2-phenyl-1-cyclopropanecarbonyl chloride 
• 100-42-5 styrene 
• 98-86-2 acetophenone 
• 94-41-7 benzalacetophenone 

Downstream Products

• 58692-65-2 1-Phenyl-1-(2-phenyl-cyclopropyl)-ethanol 
• 107487-41-2 4-hydroxy-1,4-diphenylbutan-1-one 
• 5407-91-0 1,4-diphenylbutan-1-one 
• 90364-78-6 phenyl (2-phenylcyclopropyl)-methanol 
• 126525-18-6 N-(4-Oxo-1,4-diphenyl-butyl)-acrylamide 
• 126525-17-5 N-(4-Oxo-1,4-diphenyl-butyl)-acetamide 
• 1003597-74-7 C₁₈H₁₆O 
• 886-65-7 trans,trans-1,4-Diphenyl-1,3-butadiene 
• 140654-05-3 1-Methoxy-4-((1E,3E)-1-methyl-4-phenyl-buta-1,3-dienyl)-benzene 
• 58692-66-3 (E)-1,4-diphenylpent-3-en-1-ol 
• 1181658-13-8 4-(3-hydroxy-3-phenyl-3-(2-phenylcyclopropyl)prop-1-ynyl)benzonitrile 
• 1181658-17-2 3-(2-methoxynaphthalen-6-yl)-1-phenyl-1-(2-phenylcyclopropyl)prop-2-yn-1-ol 
• 17572-77-9 (3E)-1,4-diphenylbut-3-en-1-one 

Relevant articles and documents

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Bioinspired Radical-Mediated Transition-Metal-Free Synthesis of N-Heterocycles under Visible Light

A redox-active iminoquinone motif connected with π-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the molecule was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcohols happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcohols under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinoline and pyrimidine. This organocatalytic approach is very mild (70 °C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

Direct α-Acylation of Alkenes via N-Heterocyclic Carbene, Sulfinate, and Photoredox Cooperative Triple Catalysis

N-Heterocyclic carbene (NHC) catalysis has emerged as a versatile tool in modern synthetic chemistry. Further increasing the complexity, several processes have been introduced that proceed via dual catalysis, where the NHC organocatalyst operates in concert with a second catalytic moiety, significantly enlarging the reaction scope. In biological transformations, multiple catalysis is generally used to access complex natural products. Guided by that strategy, triple catalysis has been studied recently, where three different catalytic modes are merged in a single process. In this Communication, direct α-C-H acylation of various alkenes with aroyl fluorides using NHC, sulfinate, and photoredox cooperative triple catalysis is reported. The method allows the preparation of α-substituted vinyl ketones in moderate to high yields with excellent functional group tolerance. Mechanistic studies reveal that these cascades proceed through a sequential radical addition/coupling/elimination process. In contrast to known triple catalysis processes that operate via two sets of interwoven catalysis cycles, in the introduced process, all three cycles are interwoven.

Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method

An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcohols following "borrowing hydrogen". A one-pot, cascade C3-alkylation starting from 2-aminophenyl ethyl alcohols, and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality. This journal is