153114-32-0Relevant articles and documents
Improved Method for the Preparation of Guanidines
Kim, Kyoung Soon,Qian, Ligang
, p. 7677 - 7680 (1993)
Use of N,N'-di-(tert-butoxycarbonyl)thiourea 1 in the presence of mercuric chloride provides a very efficient method for the bis-Boc protected guanidine formation of the amino compounds which are highly deactivated either sterically or electronically.
Synthesis of guanidines via the I2 mediated desulfurization of N,N′-di-Boc-thiourea
Rong, Hao-Jie,Yang, Cui-Feng,Chen, Tao,Wang, Yong-Qiang,Ning, Bin-Ke
supporting information, (2019/07/30)
The I2 mediated desulfurization of N,N′-di-Boc-thiourea was developed. Various primary amines, including sterically and electronically deactivated primary amines, were transformed into the corresponding bis-Boc protected guanidines under mild conditions.