153259-61-1Relevant articles and documents
Method for treating COPD
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, (2008/06/13)
A method for treating COPD is disclosed comprising administering compounds of Formula (I) wherein the terms R1, R3, X, X2and Z are herein defined.
Compounds useful for treating allergic and inflammatory diseases
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, (2008/06/13)
Novel compounds of Formula (I) STR1 where X4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.