153282-62-3Relevant articles and documents
Phenyl carboxamide isoxazoles
-
, (2008/06/13)
A compound selected from the group consisting of a compound of the formula STR1 wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 3 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, R3 is --COOR6, R6 is hydrogen or alkyl of 1 to 3 carbon atoms, R4 is selected from the group consisting of halogen, --CN, --NO2, --SCH3, alkylcarbonyl of 1 to 6 alkyl carbon atoms, --CX3, --WCX3, --(CH2)n --CX3, --(CX2)n --CX3, --W--(CX2)n --CX3, and --W--(CH2)n --CX3, X is halogen, W is --O-- or --S--, n is 1, 2 or 3, R5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms and their salts with non-toxic pharmaceutically acceptable bases with the proviso that if R2 is alkyl of 1 to 3 carbon atoms, R1 is hydrogen and R4 is selected from the group consisting of halogen, --CX3, --(CH2)n --CX3, --(CX2)n --CX3, --OCX3, --O--(CX2)n --CX3, and --O--(CH2)n --CX3, X is halogen and n is 1, 2 or 3, R5 cannot be hydrogen having anti-inflammatory activity and their preparation and intermediates.