153333-22-3Relevant articles and documents
Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester-AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors
Manyeruke, Meloddy H.,Olomola, Temitope O.,Majumder, Swarup,Abrahams, Shaakira,Isaacs, Michelle,Mautsa, Nicodemus,Mosebi, Salerwe,Mnkandhla, Dumisani,Hewer, Raymond,Hoppe, Heinrich C.,Klein, Rosalyn,Kaye, Perry T.
, p. 7521 - 7528 (2015/12/18)
Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition
Evaluation of Baylis-Hillman Routes to 3-(Aminomethyl)coumarin Derivatives
Olasupo, Idris,Rose, Nathan R.,Klein, Rosalyn,Adams, Luqman A.,Familoni, Oluwole B.,Kaye, Perry T.
, p. 251 - 258 (2013/12/04)
The relative merits of two different Baylis-Hillman approaches toward the preparation of coumarin derivatives, containing peptide-like side chains, have been explored. In one approach, use of methyl acrylate as the activated alkene requires a protecting group strategy, an approach that is not necessary when using tert-butyl acrylate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
Regio-Controlled Michaelis-Arbuzov reactions of 3-(halomethyl)-coumarins
Rashamuse, Thompo J.,Musa, Musiliyu A.,Klein, Rosalyn,Kaye, Perry T.
scheme or table, p. 302 - 305 (2009/12/25)
3-(Iodomethyl)coumarins and 3-(chloromethyl)coumarins, obtained chemoselectively via Baylis-Hillman reactions of salicylaldehyde derivatives with t-butyl acrylate, can be reacted with triethyl phosphite to afford regioisomeric Michaelis-Arbuzov products.
