153373-42-3

Basic information

• Product Name: 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride
• Synonyms: 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride
• CAS NO: 153373-42-3
• Molecular Weight: 363.8
• Mol File: 153373-42-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride(153373-42-3)
• EPA Substance Registry System: 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride(153373-42-3)

Safety Data

• Hazardous Substances Data: 153373-42-3(Hazardous Substances Data)

Upstream product

• 548-93-6 3-hydroxyanthranilic acid 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 186501-21-3 2-(2-(benzyloxy)benzoylamino)-3-hydroxybenzoic acid methyl ester 
• 186501-24-6 methyl 2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylate 
• 100-39-0 benzyl bromide 
• 17672-21-8 2-amino-3-hydroxy-benzoic acid methyl ester 
• 55142-16-0 methyl 2-(benzyloxy)benzoate 
• 4349-62-6 2-benzyloxybenzoyl chloride 
• 14389-86-7 2-benzyloxybenzoic acid 
• 186501-25-7 2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid 

Downstream Products

• 151271-53-3 2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester 
• 186501-26-8 methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate 

Relevant articles and documents

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.

The total synthesis of UK-1

A concise, five-step total synthesis of UK-1, a novel bis(benzoxazole) metabolite of Streptomyces sp. 517-02, was accomplished. The methyl ether of UK-1 was also synthesized in 3 steps using the same methodology. Both syntheses are accomplished by the seq