153466-65-0 Usage
Description
DICLOFENAC-D4 is a deuterated form of diclofenac, a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. It is characterized by its off-white crystalline solid appearance and has an overall isotopic purity of 92%, with a representative lot composition of 75% d4, 23% d3, and 2% d2.
Uses
Used in Pharmaceutical Industry:
DICLOFENAC-D4 is used as an internal standard for the quantification of diclofenac by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry (MS). This application is crucial for ensuring accurate measurements and analysis of diclofenac in various pharmaceutical formulations.
DICLOFENAC-D4 is used as an active metabolite for diclofenac methyl ester and diclofenac amide, which are also NSAIDs and COX inhibitors. This makes it a valuable compound in the development and study of new anti-inflammatory drugs.
Used in Research and Development:
DICLOFENAC-D4 is used as a research tool to study the inhibition of arachidonic acid release induced by A23187 in isolated rat peritoneal neutrophils and macrophages. This helps in understanding the anti-inflammatory mechanisms of diclofenac and its potential applications in treating various inflammatory conditions.
Used in Preclinical Studies:
DICLOFENAC-D4 is used in preclinical studies to evaluate the efficacy of transdermal administration of diclofenac in inhibiting carrageenan-induced paw edema in rats. This helps in assessing the potential of diclofenac formulations for the treatment of pain associated with various conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Check Digit Verification of cas no
The CAS Registry Mumber 153466-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,4,6 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 153466-65:
(8*1)+(7*5)+(6*3)+(5*4)+(4*6)+(3*6)+(2*6)+(1*5)=140
140 % 10 = 0
So 153466-65-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1/i1D,2D,4D,7D;
153466-65-0Relevant articles and documents
Preparation of labeled human drugmetabolites and drug-drug interaction-probes with fungal peroxygenases
Poraj-Kobielska, Marzena,Atzrodt, Jens,Holla, Wolfgang,Sandvoss, Martin,Groebe, Glenn,Scheibner, Katrin,Hofrichter, Martin
, p. 513 - 519 (2014/03/21)
Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic molecule
Synthesis of deuterium labelled diclofenac with improved isotopic enrichment
Keying, Wu,Lei, Tian,Hongye, Li,Jian, Li,Liqin, Chen
experimental part, p. 535 - 537 (2010/07/02)
A five-step synthesis of deuterium-labelled diclofenac starting from 2-phenyl[2H5] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic
