153487-88-8Relevant articles and documents
MULTISUBSTRATE ANALOGUE INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE BASED ON 5-DEAZAACYCLOTETRAHYDROFOLATE (5-DACTHF)
Bigham, Eric C.,Mallory, W. Revill,Hodson, Steven J.,Duch, David S.,Ferone, Robert,Smith, Gary K.
, p. 1289 - 1307 (2007/10/02)
N10-Substituted acetyl derivatives of 5-DACTHF are less active in general than the parent.However, multisubstrate analogue inhibitors that are 1000-fold more potent were synthesized, and N10-pyruvoyl-5-DACTHF serves as a precursor fo