153537-73-6 Usage
Description
Plevitrexed is a novel non-polyglutamated thymidylate synthase inhibitor, which is a type of chemotherapy drug. It is designed to target and inhibit the enzyme thymidylate synthase, which plays a crucial role in the synthesis of DNA. By inhibiting this enzyme, Plevitrexed disrupts the process of DNA replication and repair, ultimately leading to the death of cancer cells.
Uses
Used in Oncology:
Plevitrexed is used as an anticancer agent for adult patients with solid tumors. It is particularly effective in treating various types of cancer, including liver, breast, lung, pancreatic, colorectal, and ovarian cancers. The drug modulates several oncological signaling pathways, such as JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R, VEGF/VEGFR, and CXCL12/CXCR4 axes, exerting inhibitory effects on tumor growth and progression.
Additionally, Plevitrexed demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases. This combination therapy can improve the overall treatment outcomes for patients with solid tumors.
Check Digit Verification of cas no
The CAS Registry Mumber 153537-73-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,5,3 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 153537-73:
(8*1)+(7*5)+(6*3)+(5*5)+(4*3)+(3*7)+(2*7)+(1*3)=136
136 % 10 = 6
So 153537-73-6 is a valid CAS Registry Number.
InChI:InChI=1/C26H25FN8O4/c1-4-9-35(13-16-11-19-22(10-14(16)2)28-15(3)29-25(19)37)17-5-6-18(20(27)12-17)24(36)30-21(26(38)39)7-8-23-31-33-34-32-23/h1,5-6,10-12,21H,7-9,13H2,2-3H3,(H,30,36)(H,38,39)(H,28,29,37)(H,31,32,33,34)/t21-/m0/s1
