153547-60-5

Basic information

• Product Name: 1,2-Propanediol, 3-(2-chlorophenoxy)-, (2R)-
• CAS NO: 153547-60-5
• Molecular Formula: C9H11ClO3
• Molecular Weight: 202.638
• Mol File: 153547-60-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 3-(2-chlorophenoxy)-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 3-(2-chlorophenoxy)-, (2R)-(153547-60-5)
• EPA Substance Registry System: 1,2-Propanediol, 3-(2-chlorophenoxy)-, (2R)-(153547-60-5)

Safety Data

• Hazardous Substances Data: 153547-60-5(Hazardous Substances Data)

Upstream product

• 95-57-8 2-monochlorophenol 
• 57044-25-4 (R)-oxiranemethanol 
• 2212-04-6 1-(2-chlorophenoxy)-2,3-epoxypropane 
• 206259-32-7 (4R,5R)-2-chloro-N,N,N',N'-tetramethyl-1,3,2-dioxaphospholane-4,5-dicarboxamide 
• 147220-29-9 1-acetoxy-3-(2-chlorophenoxy)propan-2-ol 
• 5112-21-0 rac-3-(2-chlorophenoxy)propane-1,2-diol 
• 204584-21-4 1-acetoxy-3-(2-chlorophenoxy)propan-2-one 
• 147220-39-1 Acetic acid (S)-1-acetoxymethyl-2-(2-chloro-phenoxy)-ethyl ester 

Downstream Products

• 128994-26-3 (R)-(-)-1-(2-chlorophenoxy)-2,3-epoxypropane 

Relevant articles and documents

Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers

The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding (S)-epoxides with up to >99% ee and (R)-diols with up to 89% ee. The enantiomeric ratio (E) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E=39.

Jacobsen-type enantioselective hydrolysis of aryl glycidyl ethers. 31P NMR analysis of the enantiomeric composition of oxiranes

The enantioselective partial hydrolysis of a number of racemic aryl glycidyl ethers in the presence of chiral Co(salen)-catalyst was studied. The enantiomeric composition of the isolated (R)-aryl glycidyl ethers was analyzed by 31P NMR using optically active substituted 2-chloro-1,3,2- dioxaphospholanes. A synthesis of β-adrenoblocking agents (S)-toliprolol and (S)-moprolol based on the simultaneously obtained (S)-3-aryloxypropane-1,2- diols was proposed.

Studies on agents with vasodilator and β-blocking activities. III synthesis and activity of optical isomers of TZC-1370

Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2- chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of β-blocking activity than the (R)-isomer, while