153645-34-2

Basic information

• Product Name: 2-Hydroxy-N-((R)-1-phenyl-ethyl)-acetamide
• Synonyms: 2-Hydroxy-N-((R)-1-phenyl-ethyl)-acetamide
• CAS NO: 153645-34-2
• Molecular Weight: 179.219
• Mol File: 153645-34-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-N-((R)-1-phenyl-ethyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-N-((R)-1-phenyl-ethyl)-acetamide(153645-34-2)
• EPA Substance Registry System: 2-Hydroxy-N-((R)-1-phenyl-ethyl)-acetamide(153645-34-2)

Safety Data

• Hazardous Substances Data: 153645-34-2(Hazardous Substances Data)

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 623-50-7 ethyl 2-hydroxyacetate 
• 185527-09-7 (R)-N-(1-phenylethyl)oxalamic acid 
• 79-14-1 glycolic Acid 

Relevant articles and documents

A simple preparation of amides from acids and amines by heating of their mixture

Heating a mixture of an amine and an acid is demonstrated as the method of choice for the preparation of many amides. The yields depend on the physical properties and thermal stability of the reactants and range from good to excellent. The ideal reactants

Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction

A streamlined and high-yielding synthesis of aprepitant (1), a potent substance P (SP) receptor antagonist, is described. The enantiopure oxazinone 16 starting material was synthesized via a novel crystallization-induced dynamic resolution process. Conversion of 16 to the penultimate intermediate cis-sec-amine 9 features a highly stereoselective Lewis acid-catalyzed trans acetalization of chiral alcohol 3 with trichloroacetimidate 18 followed by inversion of the adjacent chiral center on the morpholine ring. The six-step process for the synthesis of 9 was accomplished in extremely high overall yield (81%) and with only two isolations.