1536473-72-9 Usage
Description
t-BuBrettPhos Palladacycle Gen. 3, also known as tBuBrettPhos Pd G3, is a third-generation Buchwald precatalyst designed for cross-coupling reactions. It is characterized by its air, moisture, and thermal stability, as well as its high solubility in a wide range of common organic solvents. This precatalyst offers unique advantages such as lower catalyst loadings, shorter reaction times, efficient formation of the active catalytic species, and precise control of the ligand-to-palladium ratio.
Uses
Used in Pharmaceutical Industry:
t-BuBrettPhos Palladacycle Gen. 3 is used as a precatalyst for the N-arylation of amino acid esters with aryl triflates. This application is particularly relevant in the pharmaceutical industry, as it allows for the synthesis of various drug molecules under mild reaction conditions and minimal racemization of the amino acid ester.
Used in Chemical Synthesis:
In the field of chemical synthesis, t-BuBrettPhos Palladacycle Gen. 3 is utilized to catalyze the conversion of aryl halides to phenols in the presence of benzaldoxime as a hydroxide surrogate. This process is valuable for the production of various chemical compounds and intermediates.
Used in Cross-Coupling Reactions:
t-BuBrettPhos Palladacycle Gen. 3 is employed as a catalyst in cross-coupling reactions for the formation of various carbon-based bonds, such as C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. These reactions are essential in the synthesis of complex organic molecules and materials, making this precatalyst a versatile tool in organic chemistry.
Reaction
Palladium catalyst used for the arylation of primary amides.
Palladium catalyst used for the synthesis of N-aryl carbamates.
Palladium catalyst used for the N-monoarylation of amidines.
Palladium catalyst used for the cross-coupling of aryl chlorides and triflates with sodium cyanate – a practical synthesis of unsymmetrical ureas.
Palladium catalyst used in the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5]pyrazines through amidation of 2-chloro-3-amino-heterocycles.
Palladium catalyst used in the N-arylation of 2-aminothiazoles
Palladium catalyst used in the synthesis of diarylethers under mild conditions.
Palladium catalyst used in the hydroxylation of aryl and heteroaryl halides.
Check Digit Verification of cas no
The CAS Registry Mumber 1536473-72-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,6,4,7 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1536473-72:
(9*1)+(8*5)+(7*3)+(6*6)+(5*4)+(4*7)+(3*3)+(2*7)+(1*2)=179
179 % 10 = 9
So 1536473-72-9 is a valid CAS Registry Number.