1537-52-6 Usage
Description
2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER is an organic compound that serves as a crucial intermediate in various chemical reactions and synthesis processes. It is characterized by its unique molecular structure, which includes a bromo and a fluoro group attached to a propionic acid esterified with a methyl group. 2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER is known for its reactivity and versatility in organic synthesis, making it a valuable component in the development of new molecules and materials.
Uses
Used in Organic Synthesis:
2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a wide range of reactions, including substitution, addition, and elimination processes. This versatility makes it an essential building block in the creation of complex molecules and materials.
Used in Peptide Synthesis:
In the field of peptide synthesis, 2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER is employed as a valuable intermediate for the formation of peptide bonds. Its reactivity and stability contribute to the efficient synthesis of peptides, which are essential components in the development of new drugs and bioactive molecules.
Used in Asymmetric Synthesis:
2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER is also utilized in asymmetric synthesis, a technique that allows for the selective formation of one enantiomer over another. 2-BROMO-3-FLUOROPROPIONIC ACID METHYL ESTER's unique structure and reactivity make it an ideal candidate for the development of chiral molecules, which are crucial in the pharmaceutical industry for their potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1537-52-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,3 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1537-52:
(6*1)+(5*5)+(4*3)+(3*7)+(2*5)+(1*2)=76
76 % 10 = 6
So 1537-52-6 is a valid CAS Registry Number.
1537-52-6Relevant articles and documents
OXYDATIVE NUCLEOPHILIC FLUORINATION OF C-Br BONDS. NEW PREPARATIVE APPLICATIONS
Boguslavskaya, L. S.,Chuvatkin, N. N.
, p. 138 (1991)
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REACTIONS OF HALOGEN FLUORIDES. XIII. NEW POSSIBILITIES FOR OXIDATIVE NUCLEOPHILIC FLUORINATION OF BROMINE-SUBSTITUTED ESTERS BY THE HEXACHLOROMELAMINE-HYDROGEN FLUORIDE SYSTEM
Chuvatkin, N. N.,Panteleeva, I. Yu.,Kurskii, Yu. A.,Boguslavskaya, L. S.
, p. 1450 - 1456 (2007/10/02)
Primary, secondary, and tertiary bromine atoms in bromine-substituted esters, including the bromine atoms of the CBr2 group at the α position to the ester group, are substituted effectively by a bromine atom in the hexachloromelamine-liquid hydrogen fluoride system under normal conditions.New methods were developed for the production of alkyl and fluoroalkyl 2,3-dihalogeno-2-fluoropropionates, which are key compounds in the synthesis of α-fluoroacrylates.
REACTIONS OF HALOGEN FLUORIDES XII. REACTION OF BROMINE TRIFLUORIDE WITH BROMINE-CONTAINING ESTERS. A NEW METHOD FOR THE SYNTHESIS OF FLUOROALKYL 2-FLUOROACRYLATES
Kartashov, A. V.,Chuvatkin, N. N.,Boguslavskaya, L. S.
, p. 2243 - 2248 (2007/10/02)
Being weak Lewis bases, esters reduce the reactivity of bromine trifluoride in the substitutive fluorination of organic bromine derivatives.For this reason the rate of the reaction of bromine trifluoride with bromine-containing esters depends not only on the electronic characteristics of the substituents at the reaction center but also on the basicity of the ester.As a rule, the selectivity of the reaction increases with increase in the basicity of the ester.The reaction of bromine trifluoride or chlorine monofluoride with fluoroalkyl 2,3-dibromopropionates can be used successfully for the synthesis of monomers (fluoroalkyl 2-fluoroacrylates).
