1537168-43-6

Basic information

• Product Name: 2-{1-[2-([1,1′-biphenyl]-4-yl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide
• CAS NO: 1537168-43-6
• Molecular Weight: 349.459
• Mol File: 1537168-43-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{1-[2-([1,1′-biphenyl]-4-yl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{1-[2-([1,1′-biphenyl]-4-yl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide(1537168-43-6)
• EPA Substance Registry System: 2-{1-[2-([1,1′-biphenyl]-4-yl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide(1537168-43-6)

Safety Data

• Hazardous Substances Data: 1537168-43-6(Hazardous Substances Data)

Upstream product

• 3815-20-1 biphenyl-4-carboxylic acid amide 
• 13363-50-3 4-phenylthiobenzamide 
• 1694-29-7 3-chloropentane-2,4-dione 
• 1303709-11-6 1-[4-methyl-2-((1,1′-biphenyl)-4-yl)thiazol-5-yl]ethanone 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 3218-36-8 4-Phenylbenzaldehyde 

Relevant articles and documents

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.