15382-71-5Relevant articles and documents
Photochemical C–H Activation: Generation of Indole and Carbazole Libraries, and First Total Synthesis of Clausenawalline D
Alimi, Isak,Remy, Richard,Bochet, Christian G.
, p. 3197 - 3210 (2017/06/21)
The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.
Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase
Scott, David A.,Balliet, Carrie L.,Cook, Donald J.,Davies, Audrey M.,Gero, Thomas W.,Omer, Charles A.,Poondru, Srinivasu,Theoclitou, Maria-Elena,Tyurin, Boris,Zinda, Michael J.
scheme or table, p. 697 - 700 (2009/08/15)
3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.
