15386-94-4

Basic information

• Product Name: N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE
• Synonyms: N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE
• CAS NO: 15386-94-4
• Molecular Formula: C₁₁H₈F₃NO₂
• Molecular Weight: 243.18
• Mol File: 15386-94-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 403.9°C at 760 mmHg
• Flash Point: 198.1°C
• Appearance: /
• Density: 1.426g/cm³
• Vapor Pressure: 9.8E-07mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE(15386-94-4)
• EPA Substance Registry System: N-(3-(TRIFLUOROMETHYL)PHENYL)SUCCINIMIDE(15386-94-4)

Safety Data

• Hazardous Substances Data: 15386-94-4(Hazardous Substances Data)

Usage

General Description

N-(3-(trifluoromethyl)phenyl)succinimide is a chemical compound with the molecular formula C12H8F3NO2. It is an organic compound with a white powdery appearance at room temperature. This chemical is used in various applications such as in the pharmaceutical industry, where it acts as an intermediate for the synthesis of other compounds. It is also used as an intermediate in the production of pesticides, herbicides, and other agricultural chemicals. Additionally, N-(3-(trifluoromethyl)phenyl)succinimide has been studied for its potential anti-inflammatory and anti-cancer properties. However, it is important to handle this chemical with caution and follow proper safety protocols when working with it.

InChI:InChI=1/C11H8F3NO2/c12-11(13,14)7-2-1-3-8(6-7)15-9(16)4-5-10(15)17/h1-3,6H,4-5H2

Upstream product

• 123-56-8 Succinimide 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 368-49-0 3-(trifluoromethyl)phenyllithium 
• 108-30-5 succinic acid anhydride 
• 98-16-8 3-trifluoromethylaniline 

Relevant articles and documents

Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis

The thiazolidinone 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTRinh-172) inhibits cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel conductance with submicromolar affinity and blocks cholera toxin-induced intestinal fluid secretion. Fifty-eight CFTRinh-172 analogs were synthesized to identify CFTR inhibitors with improved water solubility, exploring modifications in its two phenyl rings, thiazolidinone core, and core-phenyl connectors. Greatest CFTR inhibition potency was found for 3-CF3 and polar group-substituted-phenyl rings, and a thiazolidinone core. Two compounds with ～1 μM CFTR inhibition potency and solubility >180 μM (>10-fold more than CFTRinh-172) were identified: Tetrazolo-172, containing 4-tetrazolophenyl in place of 4-carboxyphenyl, and Oxo-172, containing thiazolidinedione in place of the thiazolidinone core. These water soluble thiazolidinone analogs had low cellular toxicity. The improved water solubility of Tetrazolo- and Oxo-172 make them potential lead candidates for therapy of secretory diarrheas and polycystic kidney disease.