1538605-84-3Relevant articles and documents
R -configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi
Choi, Jun Yong,Calvet, Claudia M.,Vieira, Debora F.,Gunatilleke, Shamila S.,Cameron, Michael D.,McKerrow, James H.,Podust, Larissa M.,Roush, William R.
, p. 434 - 439 (2014/05/06)
Sterol 14α-demethylase (CYP51) is an important therapeutic target for fungal and parasitic infections due to its key role in the biosynthesis of ergosterol, an essential component of the cell membranes of these pathogenic organisms. We report the developm