153870-20-3 Usage
Description
S-acetyl-PEG3-alcohol is a PEG (polyethylene glycol) linker that features a sulfur acetyl group and a hydroxyl group. This unique structure allows for the sulfur acetyl group to be removed, resulting in the formation of a thiol moiety. The hydroxyl group can then be utilized to further modify the compound through chemical reactions. The presence of hydrophilic PEG linkers significantly enhances the water solubility of the compound in aqueous environments.
Uses
Used in Pharmaceutical Industry:
S-acetyl-PEG3-alcohol is used as a versatile building block for the development of novel pharmaceutical compounds. The ability to generate a thiol moiety upon removal of the sulfur acetyl group makes it a valuable component in the synthesis of various therapeutic agents. Additionally, the hydroxyl group provides a reactive site for further chemical modifications, allowing for the creation of a diverse range of drug candidates with tailored properties.
Used in Drug Delivery Systems:
In the field of drug delivery, S-acetyl-PEG3-alcohol is utilized as a key component in the design of targeted and controlled release systems. The hydrophilic nature of the PEG linkers can improve the solubility and stability of drug carriers, while the thiol moiety generated after the removal of the sulfur acetyl group can be employed for specific interactions with biological targets or for the attachment of drug molecules. This dual functionality makes S-acetyl-PEG3-alcohol an attractive option for the development of advanced drug delivery platforms.
Used in Bioconjugation and Protein Engineering:
S-acetyl-PEG3-alcohol is used as a versatile linker in bioconjugation and protein engineering applications. The thiol moiety generated after the removal of the sulfur acetyl group can be employed for the selective and stable attachment of various biomolecules, such as peptides, proteins, or nucleic acids. This allows for the creation of novel bioconjugates with improved properties, such as enhanced solubility, stability, and bioavailability.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, S-acetyl-PEG3-alcohol is used as an ingredient in various formulations due to its ability to improve the solubility and stability of active ingredients. The hydrophilic PEG linkers can enhance the water solubility of hydrophobic compounds, making them more compatible with aqueous formulations. Additionally, the thiol moiety generated after the removal of the sulfur acetyl group can be used for the development of novel antioxidant or anti-aging agents, providing potential benefits for skin health and appearance.
Check Digit Verification of cas no
The CAS Registry Mumber 153870-20-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,8,7 and 0 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 153870-20:
(8*1)+(7*5)+(6*3)+(5*8)+(4*7)+(3*0)+(2*2)+(1*0)=133
133 % 10 = 3
So 153870-20-3 is a valid CAS Registry Number.
153870-20-3Relevant articles and documents
Synthesis of reactive polymers for acrolein capture using AGET ATRP
Beringer, Laura T.,Li, Shaohua,Gilmore, Gary,Lister, John,Averick, Saadyah
, p. 3776 - 3781 (2015)
Acrolein is a toxic metabolite of the anticancer agent cyclophosphamide (CP). Current strategies to mitigate acrolein toxicity are insufficient, and in this brief article, we report the synthesis of well-defined low molecular weight block copolymers using activators generated by electron transfer atom transfer radical polymerization (AGET ATRP) capable of reacting with the cytotoxic small molecule acrolein. Acrolein reactivity was introduced into the block copolymers via incorporation of either (a) aminooxy or (b) sulfhydryl groups. The cytoprotective effect of the polymers was compared to sodium 2-sulfanylethanesulfonate (mesna) the current gold standard for protection from CP urotoxicity, and we found that the polymers bearing sulfhydryl moieties demonstrated superior cytoprotective activity.
Hetero-Click Conjugation of Oligonucleotides with Glycosides Using Bifunctional Phosphoramidites
Meyer, Albert,No?l, Mathieu,Vasseur, Jean-Jacques,Morvan, Fran?ois
, p. 2921 - 2927 (2015)
Two phosphoramidite derivatives, 1 and 2, each bearing two orthogonal functions: alkyne/thioacetyl or alkyne/tosyl, respectively, were synthesized and used to generate heteroglyco 5′-oligonucleotide conjugates. After coupling, the first conjugation was pe
A New Strategy for the Solid-Phase Synthesis of 5'-Thiolated Oligodeoxynucleotides
Kuijpers, Will H. A.,Boeckel, Constant A. A. van
, p. 10931 - 10944 (2007/10/02)
A novel procedure is described for the introduction of a masked thiol function at the 5'-terminus of oligodeoxynucleotides.An acetyl-protected thiol linker phosphoramidite has been prepared which can be coupled efficiently to fully protected oligonucleoti
